Document Detail


Advances in management of acute hypertension: a concise review.
MedLine Citation:
PMID:  22642919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic hypertension affects >1 billion people worldwide and >70 million people in the United States. Acute hypertensive episodes (AHE) are defined as severe spikes in blood pressure that may result in end-organ damage. Although AHE may arise independently as de novo events, they are more likely to occur in patients with pre-existing hypertension. One of the controversies regarding the clinical approach to AHE is the selection of anti-hypertensive medication. Depending on the clinical presentation of the patient and the threat of end-organ damage resulting from blood pressure elevation, appropriate and prompt treatment is warranted. There are multiple agents available for the management of hypertension. However, the greatest challenge lies in the acute care setting where the need exists for better initial and sustained control of blood pressure spikes. Many anti-hypertensive agents effectively lower blood pressure, yet only few have the capacity to achieve strict control of hypertension in the acute setting. Clevidipine butyrate is an ultra short-acting intravenous dihydropyridine calcium-channel blocker. Clevidipine has unique pharmacodynamic and pharmacokinetic properties that enable the fast, safe, and adequate reduction of blood pressure in hypertensive emergencies, with the ability to provide highly precise titration necessary to maintain a narrowly-defined target blood pressure range. Several recently published phase I, II, and III clinical studies have shown Clevidipine to be an effective blood pressure modulator in such capacity.
Authors:
David B Tulman; Stanislaw P A Stawicki; Thomas J Papadimos; Claire V Murphy; Sergio D Bergese
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Discovery medicine     Volume:  13     ISSN:  1944-7930     ISO Abbreviation:  Discov Med     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-30     Completed Date:  2012-09-26     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  101250006     Medline TA:  Discov Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  375-83     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, The Ohio State University School of Medicine, Columbus, Ohio 43210, USA.
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure
Humans
Hypertension / epidemiology,  therapy*
United States / epidemiology
Grant Support
ID/Acronym/Agency:
UL1 TR000090/TR/NCATS NIH HHS
Comments/Corrections

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