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Advances in the genetics of spondyloarthritis and clinical implications.
MedLine Citation:
PMID:  23771560     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Spondyloarthritis (SpA) is a group of inflammatory rheumatic diseases whose main clinical feature is inflammation of the axial spine. Articular, periarticular, and extra-articular manifestations can also occur, depending on the type of spondyloarthritis. The most common clinical subsets of SpA are ankylosing spondylitis (AS) and psoriatic arthritis (PsA). SpA is a major health challenge given the propensity to affect young adults and the potential requirement for lifelong treatment. Although the precise etiology of SpA is unknown, there is mounting evidence that these diseases are a result of complex interplay of genetic, environmental, and immunological factors. In this review on SpA, we will discuss genetic variants with genome-wide significance, highlight potential clinical application of genetic variants, and discuss challenges in further elucidating the genetic basis of SpA.
Authors:
Darren D O'Rielly; Proton Rahman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current rheumatology reports     Volume:  15     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-06-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, Health Sciences Centre, Rm. 1 J440, St. John's, NL, Canada, A1B 3V6, darren.orielly@med.mun.ca.
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