Document Detail

Advances in exercise, fitness, and performance genomics in 2010.
MedLine Citation:
PMID:  21499051     Owner:  NLM     Status:  MEDLINE    
This review of the exercise genomics literature emphasizes the strongest articles published in 2010 as defined by sample size, quality of phenotype measurements, quality of the exercise program or physical activity exposure, study design, adjustment for multiple testing, quality of genotyping, and other related study characteristics. One study on voluntary running wheel behavior was performed in 448 mice from 41 inbred strains. Several quantitative trait loci for running distance, speed, and duration were identified. Several studies on the alpha-3 actinin (ACTN3) R577X nonsense polymorphism and the angiotensin-converting enzyme (ACE) I/D polymorphism were reported with no clear evidence for a joint effect, but the studies were generally underpowered. Skeletal muscle RNA abundance at baseline for 29 transcripts and 11 single nucleotide polymorphisms (SNPs) were both found to be predictive of the V˙O2max response to exercise training in one report from multiple laboratories. None of the 50 loci associated with adiposity traits are known to influence physical activity behavior. However, physical activity seems to reduce the obesity-promoting effects of at least 12 of these loci. Evidence continues to be strong for a role of gene-exercise interaction effects on the improvement in insulin sensitivity after exposure to regular exercise. SNPs in the cAMP-responsive element binding position 1 (CREB1) gene were associated with training-induced HR response, in the C-reactive protein (CRP) gene with training-induced changes in left ventricular mass, and in the methylenetetrahydrofolate reductase (MTHFR) gene with carotid stiffness in low-fit individuals. We conclude that progress is being made but that high-quality research designs and replication studies with large sample sizes are urgently needed.
James M Hagberg; Tuomo Rankinen; Ruth J F Loos; Louis Pérusse; Stephen M Roth; Bernd Wolfarth; Claude Bouchard
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  43     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-08-30     Revised Date:  2014-04-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  743-52     Citation Subset:  IM; S    
Copyright Information:
© 2011 by the American College of Sports Medicine
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MeSH Terms
Adiposity / genetics,  physiology
Animal Experimentation
Athletic Performance / physiology*
Glucose / genetics,  metabolism
Hemodynamics / genetics
Insulin / genetics,  metabolism
Muscle Strength / genetics
Physical Conditioning, Animal / physiology*
Physical Endurance / genetics,  physiology
Physical Fitness / physiology*
Polymorphism, Single Nucleotide
Grant Support
HL-45670/HL/NHLBI NIH HHS; MC_U106188470//Medical Research Council; R01 HL045670/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Insulin; IY9XDZ35W2/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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