| Advances in esophageal cancer surgery in Japan: an analysis of 1000 consecutive patients treated at a single institute. | |
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MedLine Citation:
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PMID: 18374047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In Japan, most esophageal cancers are squamous cell carcinomas, and the results of esophagectomy have improved remarkably in recent years. The object of this study was to evaluate advances in operative therapy for esophageal cancer in Japan. METHOD: We evaluated mortality, morbidity, and prognosis in 1000 consecutive patients who underwent esophagectomy for esophageal cancer at a single institution in Japan. The patients were divided into 3 groups according to the period when esophagectomy was performed: Group I (n = 197), 1964-1980; group II (n = 432), 1981-1993; and group III (n = 371), 1993-2006. RESULTS: The incidence of squamous cell carcinoma was 94%. The morbidity rates were 62%, 38%, and 33 %, in groups I, II, and III, respectively (P < 0.01, groups I vs II and III), and the in-hospital mortality rates were 14.2%, 5.1%, and 2.4%, respectively (P < 0.01, between each group). The 5-year overall survival rate was 30% (14%, 27%, and 46% in groups I, II, and III, respectively; P < 0.0001). Multivariate analysis revealed age, gender, depth of invasion, node metastasis, distant metastasis, curability, extent of lymphadenectomy, resectability, and the period when the operation was performed as independent prognostic factors. CONCLUSION: Generally, esophagectomy has been performed safely without critical complications; however, the prognosis has improved remarkably with advances in surgical techniques and treatment modalities. |
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Authors:
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Masaru Morita; Rintaro Yoshida; Keisuke Ikeda; Akinori Egashira; Eiji Oki; Noriaki Sadanaga; Yoshihiro Kakeji; Takeharu Yamanaka; Yoshihiko Maehara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-04 |
Journal Detail:
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Title: Surgery Volume: 143 ISSN: 1532-7361 ISO Abbreviation: Surgery Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-31 Completed Date: 2008-04-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: United States |
Other Details:
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Languages: eng Pagination: 499-508 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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surgery* Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / surgery* Esophageal Neoplasms / surgery* Esophagectomy / adverse effects, statistics & numerical data*, trends Female Humans Japan Male Middle Aged Prognosis Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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