Document Detail


Advances in coronary microvascular dysfunction.
MedLine Citation:
PMID:  19119077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Considerable focus has been directed towards coronary arterial disease in the management of coronary heart disease, however the coronary microcirculation plays a major role in the regulation of coronary blood flow. Thus while we have multiple medical and revascularisation therapies to treat large vessel coronary artery disease, therapies directed towards the microcirculation are very limited. This review paper summarises important aspects of coronary microvascular dysfunction including (a) methods of assessment, (b) clinical classification of associated disorders, (c) possible pathophysiological mechanisms, and (d) potential therapies. Hence this will provide important background to advancing our understanding and management of coronary heart disease by targeting the coronary microcirculation.
Authors:
John F Beltrame; Filippo Crea; Paolo Camici
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-12-31
Journal Detail:
Title:  Heart, lung & circulation     Volume:  18     ISSN:  1444-2892     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-05     Completed Date:  2009-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  19-27     Citation Subset:  IM    
Affiliation:
Cardiology Unit, The Queen Elizabeth Hospital, Lyell McEwin Health Service, University of Adelaide, Adelaide, Australia. john.beltrame@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Coronary Artery Disease / pathology,  physiopathology*,  therapy*
Coronary Circulation*
Humans
Microcirculation*

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