Document Detail


Advances in cardiovascular genetics and embryology: role of transcription factors in congenital heart disease.
MedLine Citation:
PMID:  11021417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In spite of tremendous advances in diagnosis and treatment of cardiovascular disease in the young, our understanding of its cause is still incomplete. Recent studies have reported pleiotropic cardiac malformations resulting from mutations in transcription factors, a family of proteins known to play important roles in many aspects of development. Further evaluation of these important causes of cardiovascular disease in the young promises new insight into embryology of cardiac development and improved understanding of the pathophysiologic basis of cardiovascular disease in the young.
Authors:
D W Benson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  12     ISSN:  1040-8703     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-01-10     Completed Date:  2001-03-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  497-500     Citation Subset:  IM    
Affiliation:
Pediatric Cardiology, Medical University of South Carolina, Charleston, USA. bensondw@musc.edu
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / genetics
Heart / embryology
Heart Defects, Congenital / diagnosis,  genetics*,  physiopathology
Humans
Molecular Biology
Pedigree
Risk Factors
Transcription Factors / genetics*
Chemical
Reg. No./Substance:
0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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