Document Detail


Advances in the biology of cerebral cavernous malformations.
MedLine Citation:
PMID:  20975979     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECT: To provide a review of current, high-impact scientific findings pertaining to the biology of cerebral cavernous malformations (CCMs).
METHODS: A comprehensive literature review was conducted using PubMed to examine the current literature regarding the molecular biology and pathophysiology of CCMs.
RESULTS: In this literature review, a comprehensive approach is taken to review the current scientific status of CCMs. This includes discussion of molecular biology and animal models, ultrastructure and angioarchitectural features and immunological methods and hypotheses.
CONCLUSIONS: Studies examining the molecular biology of CCMs have shown that genes involved in angiogenesis, blood-brain barrier formation, cell size regulation, vascular permeability and apoptosis play critical roles in the ontogeny of this disease. In vivo work suggests the likelihood of a "two-hit mechanism" resulting in somatic mosaicism and biallelic loss of angiogenic genes. The etiological effects of angioarchitecture and immune response within these lesions further complicate the pathophysiology. Future treatment endeavors will necessitate exploitation of the multiple facets of CCM formation to maximize success at CCM prevention or obliteration.
Authors:
Jason S Hauptman; Parham Moftakhar; Andrew Dadour; Dennis Malkasian; Neil A Martin
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Publication Detail:
Type:  Journal Article     Date:  2010-10-11
Journal Detail:
Title:  Surgical neurology international     Volume:  1     ISSN:  2152-7806     ISO Abbreviation:  Surg Neurol Int     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-26     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101535836     Medline TA:  Surg Neurol Int     Country:  India    
Other Details:
Languages:  eng     Pagination:  63     Citation Subset:  -    
Affiliation:
Department of Neurosurgery, David Geffen School of Medicine at the University of California, Los Angeles, USA.
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