Document Detail


Advances in basic and clinical immunology in 2007.
MedLine Citation:
PMID:  18514804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 2007, there was significant progress in the area of basic immunology, including investigations that led to a better understanding of the function of antigen-presenting cells, such as the secretion of cytokines that inhibit or induce allergic inflammation on antigen stimulation. Mechanisms of IgE function were better characterized, and the clonality of IgE-producing B cells in allergic responses of monosensitized patients was demonstrated. The hygiene hypothesis was re-examined, with most of the evidence suggesting that the increase of atopy prevalence is best explained by the absence of T(H)1 responses rather than the absence of regulatory T cells. The effects of the environment in the allergic inflammation of the lung received new emphasis. Similar progress took place in the area of clinical immunology. Immune adverse reactions to drugs, such as the toxicity of carbamazepine-specific T cells and the safety and efficacy of drugs for the treatment of hereditary angioedema, were better characterized. There were advances in the molecular characterization of primary immunodeficiencies and their management, remarkably the discovery of signal transducer and activator of transcription 3 gene mutations as the cause of hyper-IgE syndrome. Long-term outcomes of bone marrow transplantation for severe combined immunodeficiencies confirmed the efficacy of this therapy.
Authors:
Javier Chinen; William T Shearer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-06-02
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  122     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  36-41     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Allergy and Immunology Section, Baylor College of Medicine, Houston, Tex 77030, USA. jxchinen@texaschildrenshospital.org
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MeSH Terms
Descriptor/Qualifier:
Antigen Presentation
B-Lymphocytes / immunology
Cytokines / immunology*,  metabolism
Dendritic Cells / immunology,  metabolism
Humans
Hypersensitivity / immunology*
Immune System / physiology*
Immunoglobulin E / immunology,  metabolism
Immunologic Deficiency Syndromes / immunology*,  metabolism
Mastocytosis / immunology,  metabolism
T-Lymphocytes / immunology
Grant Support
ID/Acronym/Agency:
AI069441/AI/NIAID NIH HHS; AI27551/AI/NIAID NIH HHS; AI41089/AI/NIAID NIH HHS; HD052102/HD/NICHD NIH HHS; HD41983/HD/NICHD NIH HHS; HL079533/HL/NHLBI NIH HHS; HL72705/HL/NHLBI NIH HHS; HL78522/HL/NHLBI NIH HHS; RAT003084A//PHS HHS; RR0188/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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