Document Detail

Advances in anaphylaxis and hypersensitivity reactions to foods, drugs, and insect venom.
MedLine Citation:
PMID:  12618751     Owner:  NLM     Status:  MEDLINE    
This review highlights some of the research advances in anaphylaxis and hypersensitivity reactions to foods, drugs, and insect venom that were reported primarily in this Journal from 2001 to 2002. Among the topics highlighted: Epinephrine injected intramuscularly into the thigh provides the most efficient absorption profile for adults and children; determination of serum IgE antibody-specific food allergen concentrations and atopy patch tests with foods show promise for enhanced diagnostic accuracy; numerous food allergens are now characterized on the molecular level, allowing for improved diagnostic and treatment modalities; the complex immunologic mechanisms underlying drug hypersensitivity reactions are being elucidated; venom immunotherapy improves quality of life for sufferers, and increased venom immunotherapy doses are useful in recalcitrant cases.
Scott H Sicherer
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  111     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-05     Completed Date:  2003-04-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S829-34     Citation Subset:  AIM; IM    
Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY, USA.
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MeSH Terms
Allergens / adverse effects,  immunology
Anaphylaxis / drug therapy,  immunology*
Arthropod Venoms / adverse effects*,  immunology
Clinical Trials as Topic
Drug Hypersensitivity / immunology*
Epinephrine / administration & dosage
Food Hypersensitivity / blood,  immunology*
Hypersensitivity, Immediate / etiology*,  therapy
Immunoglobulin E / blood
Injections, Intramuscular
Quality of Life
Skin Tests
Grant Support
K23 AI 01709-03/AI/NIAID NIH HHS
Reg. No./Substance:
0/Allergens; 0/Arthropod Venoms; 37341-29-0/Immunoglobulin E; 51-43-4/Epinephrine

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