| Advances in Stroke Therapy. | |
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MedLine Citation:
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PMID: 22201014 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Stroke is a leading cause of death, long-term disability, and socioeconomic costs, highlighting the urgent need for more effective treatments. Intravenous administration of tissue plasminogen activator (t-PA) is the only FDA-approved therapy to re-establish cerebral blood flow. However, because of increased risk of hemorrhage beyond 3 h post stroke, few stroke patients (1-2%) benefit from t-PA; t-PA, which has neurotoxic effects, can also aggravate the extent of reperfusion injury by increasing blood-brain barrier permeability. An alternative strategy is needed to extend the window of intervention, minimize damage from reperfusion injury, and promote brain repair leading to neurological recovery. Reactive oxygen species (ROS), generated soon after ischemia and during reperfusion and thereafter, are considered the main mediators of ischemic injury. Antioxidant enzymes such as catalase, superoxide dismutase, etc. can neutralize ROS-mediated injury but their effective delivery to the brain remains a challenge. In this article, we review various therapeutic approaches including surgical interventions, and discuss the potential of nanoparticle-mediated delivery of antioxidants for stroke therapy. |
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Authors:
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Hayder Jaffer; Viola B Morris; Desiree Stewart; Vinod Labhasetwar |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Drug delivery and translational research Volume: 1 ISSN: 2190-3948 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101540061 Medline TA: Drug Deliv Transl Res Country: - |
Other Details:
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Languages: ENG Pagination: 409-419 Citation Subset: - |
Affiliation:
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Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 NS070896-02//NINDS NIH HHS |
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