Document Detail


Advances in rheumatoid arthritis animal models.
MedLine Citation:
PMID:  21792748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimental models of rheumatoid arthritis have contributed immensely to our understanding of the pathogenesis as well as the treatment of this debilitating autoimmune disease. Significant progress has been made in the past few years in defining the role of newer cytokines and regulatory T cells, of inflammation-mediated bone and cartilage damage, and of the cholinergic anti-inflammatory pathway in modulating the disease process in arthritis. Furthermore, new therapeutic targets, including specific tyrosine kinases and proteasome subunits, have been explored. These advances offer renewed optimism for continued improvements in the management of rheumatoid arthritis.
Authors:
Kamal D Moudgil; Peter Kim; Ernest Brahn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Current rheumatology reports     Volume:  13     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2012-01-03     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  456-63     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. kmoud001@umaryland.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Arthritis, Rheumatoid / immunology*,  pathology,  therapy
Bone and Bones / pathology
Cartilage / pathology
Cytokines / metabolism
Disease Models, Animal*
Drug Delivery Systems
T-Lymphocytes, Regulatory / immunology,  pathology
Grant Support
ID/Acronym/Agency:
P01 AT002605/AT/NCCAM NIH HHS; P01 AT002605/AT/NCCAM NIH HHS; R01 AT004321/AT/NCCAM NIH HHS; R01 AT004321/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

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