| Advances in the biology and chemistry of sialic acids. | |
| | |
MedLine Citation:
|
PMID: 20020717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sialic acids are a subset of nonulosonic acids, which are nine-carbon alpha-keto aldonic acids. Natural existing sialic acid-containing structures are presented in different sialic acid forms, various sialyl linkages, and on diverse underlying glycans. They play important roles in biological, pathological, and immunological processes. Sialobiology has been a challenging and yet attractive research area. Recent advances in chemical and chemoenzymatic synthesis, as well as large-scale E. coli cell-based production, have provided a large library of sialoside standards and derivatives in amounts sufficient for structure-activity relationship studies. Sialoglycan microarrays provide an efficient platform for quick identification of preferred ligands for sialic acid-binding proteins. Future research on sialic acid will continue to be at the interface of chemistry and biology. Research efforts not only will lead to a better understanding of the biological and pathological importance of sialic acids and their diversity but also could lead to the development of therapeutics. |
| | |
Authors:
|
Xi Chen; Ajit Varki |
Related Documents
:
|
3397817 - Characterization of the n- and o-linked oligosaccharides in glycoproteins synthesized b... 668697 - 360-mhz 1h nuclear-magnetic-resonance spectroscopy of sialyl-oligosaccharides from pati... 3821397 - The major gangliosides of the bovine pineal body. 19822337 - Analysis of cmp-sialic acid transporter-like proteins in plants. 3920727 - Stimulation of calcium uptake in rat calvaria by prostacyclin. 7213777 - A comparison of the in vitro binding of alpha-tocopherol to microsomes of lung, liver, ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
|
Title: ACS chemical biology Volume: 5 ISSN: 1554-8937 ISO Abbreviation: ACS Chem. Biol. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-19 Completed Date: 2010-05-10 Revised Date: 2011-07-25 |
Medline Journal Info:
|
Nlm Unique ID: 101282906 Medline TA: ACS Chem Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 163-76 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, University of California, Davis, California 95616, USA. chen@chem.ucdavis.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bacteria
/
enzymology Combinatorial Chemistry Techniques Genetic Engineering Microarray Analysis Neuraminidase / chemistry Polysaccharides / chemistry* Polysaccharides, Bacterial / chemistry Sialic Acids* / biosynthesis, chemical synthesis, chemistry Sialyltransferases / chemistry |
| Grant Support | |
ID/Acronym/Agency:
|
P01 HL057345-12/HL/NHLBI NIH HHS; P01HL57345/HL/NHLBI NIH HHS; R01GM076360/GM/NIGMS NIH HHS; U01 CA128442-03/CA/NCI NIH HHS; U01CA128442/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Polysaccharides; 0/Polysaccharides, Bacterial; 0/Sialic Acids; EC 2.4.99.-/Sialyltransferases; EC 3.2.1.18/Neuraminidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Kinetically controlled photoinduced electron transfer switching in Cu(I)-responsive fluorescent prob...
Next Document: Photodissociation of cis-, trans-, and 1,1-Dichloroethylene in the Ultraviolet Range: Characterizati...