Document Detail


Advances and challenges in studying hepatitis C virus in its native environment.
MedLine Citation:
PMID:  20932139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Approximately 2% of the worldwide population is infected with hepatitis C virus (HCV), the major causative agent of non-A, non-B hepatitis. Although substantial progress has been made in developing tools to dissect the viral life cycle, most in vitro studies rely on hepatoma cell lines, which are functionally disparate from the natural in vivo target of the virus – hepatocytes. To gain insights into virus–host interactions, there is a need for HCV-model systems that more closely mimic the physiological environment of the liver. Here, we discuss recent advances in culture and detection systems that facilitate the study of HCV in primary cells. Use of these new models may help bridge the gap between in vitro studies and clinical research.
Authors:
Timothy Sheahan; Christopher T Jones; Alexander Ploss
Related Documents :
18724929 - Silencing hiv-1 in vivo.
12323399 - Recombinant antibody fab against the hypervariable region 1 of hepatitis c virus blocks...
20960299 - Development of novel antiviral therapies for hepatitis c virus.
21415769 - Could complement c4 be an alternative to biopsy for chronic hepatitis b histopathologic...
17952669 - Therapeutic potential of rna interference against cellular targets of hiv infection.
25312649 - The incidence of hepatocellular carcinoma is reduced in patients with chronic hepatitis...
17034529 - Elevated serum iga anticardiolipin antibody levels in adult henoch-schönlein purpura.
9448189 - An autopsy case of ki-1 lymphoma associated with hepatic failure.
17919829 - Affective differences among daily tobacco users, occasional users, and non-users.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Expert review of gastroenterology & hepatology     Volume:  4     ISSN:  1747-4132     ISO Abbreviation:  Expert Rev Gastroenterol Hepatol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278199     Medline TA:  Expert Rev Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  541-50     Citation Subset:  IM    
Affiliation:
Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, Box 64, New York, NY 10065, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / therapeutic use*
Cell Culture Techniques
Cell Line, Tumor
Disease Models, Animal
Hepacivirus / drug effects*,  growth & development,  pathogenicity
Hepatitis C / drug therapy*,  virology
Hepatocytes / drug effects*,  virology
Humans
Grant Support
ID/Acronym/Agency:
1 R01 DK085713-01/DK/NIDDK NIH HHS; F32AI084448/AI/NIAID NIH HHS; F32DK081193/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antiviral therapy for hepatitis C is associated with improved clinical outcomes in patients with adv...
Next Document:  Developing better treatments in hepatocellular carcinoma.