Document Detail

Advances and challenges in studying hepatitis C virus in its native environment.
MedLine Citation:
PMID:  20932139     Owner:  NLM     Status:  MEDLINE    
Approximately 2% of the worldwide population is infected with hepatitis C virus (HCV), the major causative agent of non-A, non-B hepatitis. Although substantial progress has been made in developing tools to dissect the viral life cycle, most in vitro studies rely on hepatoma cell lines, which are functionally disparate from the natural in vivo target of the virus – hepatocytes. To gain insights into virus–host interactions, there is a need for HCV-model systems that more closely mimic the physiological environment of the liver. Here, we discuss recent advances in culture and detection systems that facilitate the study of HCV in primary cells. Use of these new models may help bridge the gap between in vitro studies and clinical research.
Timothy Sheahan; Christopher T Jones; Alexander Ploss
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Expert review of gastroenterology & hepatology     Volume:  4     ISSN:  1747-4132     ISO Abbreviation:  Expert Rev Gastroenterol Hepatol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278199     Medline TA:  Expert Rev Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  541-50     Citation Subset:  IM    
Center for the Study of Hepatitis C, The Rockefeller University, 1230 York Avenue, Box 64, New York, NY 10065, USA.
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MeSH Terms
Antiviral Agents / therapeutic use*
Cell Culture Techniques
Cell Line, Tumor
Disease Models, Animal
Hepacivirus / drug effects*,  growth & development,  pathogenicity
Hepatitis C / drug therapy*,  virology
Hepatocytes / drug effects*,  virology
Grant Support
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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