Document Detail

Advancement of the mandible facilitates nasal breathing in human subjects sedated with midazolam.
MedLine Citation:
PMID:  10730730     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine how anterior advancement of the mandible (ADM) affects spontaneous breathing through the nasal route in healthy human volunteers sedated with intravenous midazolam. METHODS: In four subjects who exhibited nasal breathing during midazolam sedation (intravenous dose: 0.09+/-0.02 mg x kg(-1), mean +/- SD), we measured respiratory rate (RR), peak nasal inspiratory airflow rate (V(nIpeak)) peak nasal expiratory airflow rate (V(nEpeak), duty ratio (Ti/Ttot) and nasal resistance (Rn) before and after ADM. Nasal resistance was calculated by dividing the difference between nasal mask and oropharyngeal pressure by airflow rate at peak nasal inspiratory airflow. RESULTS: The RR, V(nIpeak), and V(nEpeak) increased following ADM (P<0.001, respectively). On the contrary, Ti/Ttot decreased after ADM (P<0.001). Consequently, ADM decreased Rn from 30.4+/-40.8 to 5.0+/-5.6 (cm H2O x l(-1) x sec(-1)) (mean +/- SD) (P<0.001). In these four subjects, no respiratory airflow was observed through the oral route before and after ADM. CONCLUSION: Advancement of the mandible decreases nasal resistance, thereby facilitating spontaneous breathing through the nasal route in normal humans sedated with midazolam.
Y Kawauchi; T Oshima; S Suzuki; Y Saitoh; H Toyooka
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  47     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-11     Completed Date:  2000-04-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  215-9     Citation Subset:  IM    
Department of Anesthesiology, School of Medicine, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Airway Resistance / physiology
Anesthetics, Intravenous / administration & dosage
Hypnotics and Sedatives / administration & dosage*
Inhalation / physiology
Mandible / anatomy & histology*
Midazolam / administration & dosage*
Nose / physiology*
Oropharynx / physiology
Peak Expiratory Flow Rate / physiology
Pulmonary Ventilation / physiology
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 59467-70-8/Midazolam

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