| Advancement in the examination of the human cardiac sinus node: an unexpected architecture and a novel cell type could interest the forensic science. | |
| | |
MedLine Citation:
|
PMID: 20679878 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
We have investigated the morphology of the sinus node of the human cardiac conduction system. Until today the sinus node (SN) is described as a heterogeneous system composed of 2 types of cells, namely, P or pale and T or transitional cells which are immersed in the matrix around the sinus nodal artery. T cells are said to share characteristics of P cells and of peripheral working atrial myocardial cells. This study was carried out on autoptic and explanted specimens using histochemical, immunohistochemical, and electron microscopic methods.Our investigations show that SN tissue has a quite different cellular composition, ie, spherical and/or star-shaped cells organized in clusters with long cytoplasmic processes (type P), transitional cells, similar to myocytes but with a reduced number of sarcomeres (type T) and, finally, as yet not described in the literature, fibroblast-like cells with long bi-tripolar extensions contacting cells. Interestingly, SN is squared by connective and elastic fibers geometrically arranged. Immunohistochemistry shows that the 3 cell types of the SN node express mesenchymal markers revelatory of their embryological origin. Innervation appears to be more complex than previously thought; we identified a system of synaptophysin-positive cholinergic vesicles dependent on the sympathetic system and parasympathetic fibers expressing S100 protein.Overall results indicate that the SN has an unexpected, systematic architecture. |
| | |
Authors:
|
Tiziana Balbi; Claudio Ghimenton; Gianandrea Pasquinelli; Laura Foroni; Marco Grillini; Giovanni Pierini |
Related Documents
:
|
20187118 - Injectable gellan gum hydrogels with autologous cells for the treatment of rabbit artic... 16443268 - Osteoprogenitor response to semi-ordered and random nanotopographies. 15603808 - Microgrooved fibrillar collagen membranes as scaffolds for cell support and alignment. 20831348 - Two stages in three-dimensional in vitro growth of tissue generated by osteoblastlike c... 22659498 - Chrysotoxine, a novel bibenzyl compound selectively antagonizes mpp(+), but not rotenon... 18298658 - The glycosyltransferase activities of lysyl hydroxylase 3 (lh3) in the extracellular sp... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of forensic medicine and pathology Volume: 32 ISSN: 1533-404X ISO Abbreviation: Am J Forensic Med Pathol Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8108948 Medline TA: Am J Forensic Med Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 112-8 Citation Subset: IM |
Affiliation:
|
From the *Institute of Surgical Pathology, S. Orsola-Malpighi Hospital, Bologna; †Department of Pathology, Borgo Trento Hospital, Verona; ‡Department of Anestesiological and Specialistic Surgical Sciences, University of Bologna; and §Legal Medicine Institute, University of Bologna, Bologna, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reply.
Next Document: An Immunohistochemical Profile of the So-called Bile Duct Adenoma: Clues to Pathogenesis.