Document Detail

Advanced soft palate cancer: the clinical importance of the parapharyngeal space.
MedLine Citation:
PMID:  16025055     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify the incidence of parapharyngeal space (PPS) recurrences and how they impact survival in advanced-stage soft-palate carcinoma patients. STUDY DESIGN AND SETTING: One hundred thirty-seven patients' charts were reviewed from 1971 to 1996. Inclusion criteria were patients who received a per-oral resection, discontinuous neck dissection, and postoperative adjuvant radiation therapy; 15 patients met criteria for inclusion. The incidence of PPS recurrences, regional failure, and survival were endpoints that were analyzed. RESULTS: There were no local failures in our study. Regional failures excluding the PPS (levels I-V) were 27%, and 40% occurred within the PPS. Cervical adenopathy was associated with 83% of the PPS recurrences. Median survival for PPS recurrences was 26 months, compared with 67 months for levels I-V recurrences (n = ns). CONCLUSIONS: The incidence of PPS recurrences is substantial in advanced-stage soft-palate cancer. PPS recurrences negatively impact survival; without effective salvage techniques for these recurrences or effective adjuvant therapy, poor patient outcomes can be expected.
Wade G Douglas; Nestor R Rigual; William Giese; Joseph Bauer; Sam M Wiseman; Thom R Loree; James Schwarz; Sadir Alrawi; Wesley L Hicks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  133     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2005-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Department of Head and Neck, Plastics and Reconstructive Surgery, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
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MeSH Terms
Carcinoma, Squamous Cell / epidemiology*,  pathology*,  secondary
Middle Aged
Neoplasm Recurrence, Local / epidemiology*
Neoplasm Staging
Otorhinolaryngologic Surgical Procedures
Palatal Neoplasms / pathology*
Palate, Soft
Pharyngeal Neoplasms / epidemiology*,  pathology,  secondary
Radiotherapy, Adjuvant
Retrospective Studies
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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