Document Detail

Advanced oesophageal carcinoma in an 84-year-old treated with chemoradiotherapy.
MedLine Citation:
PMID:  16989502     Owner:  NLM     Status:  MEDLINE    
We present a case of advanced oesophageal cancer with cardiac invasion in an 84-year-old male presenting with dysphagia and general malaise. Histological analysis of an endoscopic biopsy specimen revealed a poorly differentiated squamous cell carcinoma. Computed tomography indicated a thickened oesophageal wall that was compressing the left atrium, suggesting invasion of the heart, and oesophagography revealed a polypoid lesion 9 cm in length. No distant metastases were seen on computed tomography. The patient was given chemotherapy with 10 mg/m2 cisplatin on days 1 and 4 every week for 5 weeks and concurrent radiotherapy at a dose of 2 Gy five times per week (total dose 52 Gy). After 4 weeks, the mass was no longer visible on oesophagography or endoscopic examination. The patient was free of recurrence and metastases for 4.5 years. In conclusion, chemoradiotherapy may be curative in elderly patients with unresectable oesophageal carcinoma.
K Kusaka; T Itoh; K Kawaura; J Moriya; J Yamakawa; T Takahashi; M Oguchi; H Tonami; I Yamamoto; T Kanda
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of international medical research     Volume:  34     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-09-22     Completed Date:  2006-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  437-40     Citation Subset:  IM    
Department of General Medicine, Kanazawa Medical University, Ishikawa, Japan.
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MeSH Terms
Aged, 80 and over
Antineoplastic Agents / therapeutic use*
Carcinoma, Squamous Cell* / drug therapy,  pathology,  radiotherapy
Cisplatin / therapeutic use*
Combined Modality Therapy
Disease-Free Survival
Esophageal Neoplasms / drug therapy*,  pathology,  radiotherapy
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin

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