| Advanced necrotizing enterocolitis part 1: mortality. | |
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MedLine Citation:
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PMID: 22434227 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim of the Study The aim of this study was to investigate the factors associated with mortality in infants referred for the surgical treatment of advanced necrotizing enterocolitis (NEC).Methods Retrospective review of all infants with confirmed (Bell stage II or III) NEC treated in our unit during the past 8 years (January 2002 to December 2010). Data for survivors and nonsurvivors were compared using Mann-Whitney test and Fisher's exact test and are reported as median (range).Results Of the 205 infants with NEC, 35 (17%) were medically managed; 170 (83%) had surgery; 66 (32%) infants died; all had received surgery. Survivors and nonsurvivors were comparable for gestational age, birth weight, and gender distribution. Overall mortality was 32%, the highest mortality was in infants with pan-intestinal disease (86%) but remained significant in those with less severe disease (multifocal 39%; focal disease 21%). The commonest cause of mortality was multiple organ dysfunction syndrome and nearly half of the nonsurvivors had care withdrawn.Conclusion Despite improvement in neonatal care, overall mortality (32%) for advanced NEC has not changed in 10 years. Mortality is significant even with minimal bowel involvement. |
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Authors:
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M Thyoka; P de Coppi; S Eaton; K Khoo; N J Hall; J Curry; E Kiely; D Drake; K Cross; A Pierro |
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Publication Detail:
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Type: Journal Article Date: 2012-03-20 |
Journal Detail:
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Title: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie Volume: 22 ISSN: 1439-359X ISO Abbreviation: Eur J Pediatr Surg Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-03-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105263 Medline TA: Eur J Pediatr Surg Country: Germany |
Other Details:
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Languages: eng Pagination: 8-12 Citation Subset: IM |
Copyright Information:
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Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. |
Affiliation:
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Department of Surgery, Great Ormond Street Hospital and UCL Institute of Child Health, London, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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