| Advanced magnetic resonance imaging in benign hereditary chorea: study of two familial cases. | |
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MedLine Citation:
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PMID: 20803509 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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No brain abnormalities are usually detected on conventional magnetic resonance imaging (MRI) in benign hereditary chorea (BHC); there are currently no studies with advanced techniques in literature. We investigated whether conventional and advanced MRI techniques could depict regional brain abnormalities in two familial BHC patients and 24 healthy controls. No brain abnormalities on conventional scans were detectable; also, no significant differences in fractional anisotropy of the basal nuclei were observed. Volumetric analysis showed a decreased volume of the striatum bilaterally compared with controls, whereas spectroscopy demonstrated a significant increased myoinositol/creatine ratio bilaterally, a reduction of choline/creatine ratio bilaterally, and of N-acetyl-aspartate/creatine in the right putamen. With the limits of the small sample size in the patient group, these data show that, despite the absence of macroscopic changes on conventional MRI, volumetric and metabolic abnormalities are present in the basal nuclei of BHC patients. |
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Authors:
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Gloria Maccabelli; Anna Pichiecchio; Andrea Guala; Michela Ponzio; Fulvia Palesi; Diego Maranzana Rt; Guy Umberto Poloni; Stefano Bastianello; Cesare Danesino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 25 ISSN: 1531-8257 ISO Abbreviation: Mov. Disord. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 2670-4 Citation Subset: IM |
Copyright Information:
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© 2010 Movement Disorder Society. |
Affiliation:
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Neuroradiology Unit, Neurological Institute IRCCS C Mondino Foundation, Pavia, Italy. gloria.maccabelli@mondino.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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