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Advanced glycation endproducts and their pathogenic roles in neurological disorders.
MedLine Citation:
PMID:  20949363     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Glycation is implicated in neurological disorders. In some cases it plays a key role in the pathogenesis, in others it plays a co-adjuvant role or it appears as a consequence of degenerative changes and protein accumulation stemming from other pathways. In this work, we attempt to provide a concise, updated review of the major recent findings concerning glycation in neurological diseases. After a short introduction covering advanced glycation endproducts (AGEs) and the receptor for AGEs (RAGE), we will discuss the impact of glycation in central nervous system disorders including Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease, as well as peripheral diabetic polyneuropathies. Therapies directed at lowering the concentrations of RAGE ligands including AGEs, blocking RAGE signaling, preventing oxidative stress or lowering methylglyoxal (MGO) levels may significantly decrease the development of AGE-related pathologies in patients with neurological disorders. Many drugs are on the pipeline and the future clinical trials will reveal if the promising results translate into clinical application.
Authors:
Gerald Münch; Bernadette Westcott; Teresita Menini; Alejandro Gugliucci
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Publication Detail:
Type:  Journal Article     Date:  2010-10-14
Journal Detail:
Title:  Amino acids     Volume:  42     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1221-36     Citation Subset:  IM    
Affiliation:
Molecular Medicine Research Group, Department of Pharmacology, School of Medicine, University of Western Sydney, Campbelltown, NSW, 2560, Australia, g.muench@uws.edu.au.
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