| Advanced glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia. | |
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MedLine Citation:
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PMID: 19003638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Preeclampsia (PE) and diabetes mellitus (DM) are associated with oxidative stress. DM is complicated with formation of advanced glycation end products (AGEs), which are associated with oxidative stress. We hypothesized that elevated serum AGE would be found in pregnancies complicated by PE or DM. METHODS: Circulating AGEs, 8-isoprostane, vitamin E, and antioxidant capacity were analyzed from study patients. RESULTS: Serum AGE was elevated both in patients with type 1 DM and gestational DM, but not in PE, compared with controls. 8-isoprostane was elevated in patients with type 1 DM and PE compared with controls. CONCLUSION: AGEs and 8-isoprostane are not elevated in parallel in pregnancies complicated with PE or DM, suggesting biological heterogeneity. |
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Authors:
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Nina K Harsem; Kristin Braekke; Tale Torjussen; Kristian Hanssen; Anne Cathrine Staff |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 27 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2008 |
Date Detail:
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Created Date: 2008-11-12 Completed Date: 2009-02-17 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: United States |
Other Details:
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Languages: eng Pagination: 374-86 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway. niem@uus.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Case-Control Studies Diabetes, Gestational / blood* Dinoprost / analogs & derivatives, blood Female Ferric Compounds / metabolism Glycosylation End Products, Advanced / blood* Humans Lysine / analogs & derivatives*, blood Oxidative Stress Pre-Eclampsia / blood* Pregnancy Pregnancy in Diabetics / blood* Vitamin E / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Ferric Compounds; 0/Glycosylation End Products, Advanced; 1406-18-4/Vitamin E; 27415-26-5/8-epi-prostaglandin F2alpha; 551-11-1/Dinoprost; 56-87-1/Lysine; 5746-04-3/N(6)-carboxymethyllysine |
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