Document Detail

Advanced glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia.
MedLine Citation:
PMID:  19003638     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Preeclampsia (PE) and diabetes mellitus (DM) are associated with oxidative stress. DM is complicated with formation of advanced glycation end products (AGEs), which are associated with oxidative stress. We hypothesized that elevated serum AGE would be found in pregnancies complicated by PE or DM.
METHODS: Circulating AGEs, 8-isoprostane, vitamin E, and antioxidant capacity were analyzed from study patients.
RESULTS: Serum AGE was elevated both in patients with type 1 DM and gestational DM, but not in PE, compared with controls. 8-isoprostane was elevated in patients with type 1 DM and PE compared with controls.
CONCLUSION: AGEs and 8-isoprostane are not elevated in parallel in pregnancies complicated with PE or DM, suggesting biological heterogeneity.
Nina K Harsem; Kristin Braekke; Tale Torjussen; Kristian Hanssen; Anne Cathrine Staff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  27     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-17     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-86     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Case-Control Studies
Diabetes, Gestational / blood*
Dinoprost / analogs & derivatives,  blood
Ferric Compounds / metabolism
Glycosylation End Products, Advanced / blood*
Lysine / analogs & derivatives*,  blood
Oxidative Stress
Pre-Eclampsia / blood*
Pregnancy in Diabetics / blood*
Vitamin E / blood
Young Adult
Reg. No./Substance:
0/Biological Markers; 0/Ferric Compounds; 0/Glycosylation End Products, Advanced; 1406-18-4/Vitamin E; 27415-26-5/8-epi-prostaglandin F2alpha; 5746-04-3/N(6)-carboxymethyllysine; B7IN85G1HY/Dinoprost; K3Z4F929H6/Lysine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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