Document Detail


Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study.
MedLine Citation:
PMID:  15851628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the associations of pulse pressure (a measure of arterial stiffness) with the early glycation products hemoglobin A1c (HbA1c) and Amadori albumin and the advanced glycation end products pentosidine, Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine in a large group of type 1 diabetic individuals of the EURODIAB Prospective Complications Study. We did a cross-sectional nested case-control study from the EURODIAB Prospective Complications Study of 543 (278 men) European individuals with type 1 diabetes diagnosed at <36 years of age. We used linear regression analyses to investigate the association of pulse pressure with glycation products. Pulse pressure was significantly associated with plasma levels of Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine but not with HbA1c, Amadori albumin, and urinary levels of pentosidine. Regression coefficients adjusted for age, sex, mean arterial pressure, and duration of diabetes were 0.09 mm Hg (P=0.003) per 1 microM/M lysine Nepsilon-(carboxymethyl)lysine; 0.24 mm Hg (P=0.001) and -0.03 mm Hg (P=0.62) per 1 microM/M lysine Nepsilon-(carboxyethyl)lysine (in individuals with and without complications, respectively; P interaction=0.002); and 0.50 mm Hg (P=0.16) per 1% HbA1c; 0.07 mm Hg (P=0.12) per 1 U/mL Amadori albumin; and 0.77 mm Hg (P=0.48) per 1 nmol/mmol creatinine pentosidine. In young type 1 diabetic individuals, arterial stiffness is strongly associated with the advanced glycation end products Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine. These findings suggest that the formation of advanced glycation end products is an important pathway in the development of arterial stiffness in young type 1 diabetic individuals.
Authors:
Miranda T Schram; Casper G Schalkwijk; Aart H Bootsma; John H Fuller; Nish Chaturvedi; Coen D A Stehouwer;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-25
Journal Detail:
Title:  Hypertension     Volume:  46     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2005-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure*
Case-Control Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 1 / blood,  physiopathology*
Female
Follow-Up Studies
Hemoglobin A, Glycosylated / metabolism
Humans
Linear Models
Lysine / analogs & derivatives,  blood
Male
Middle Aged
Multicenter Studies as Topic
Platelet Activating Factor / metabolism*
Prospective Studies
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/Platelet Activating Factor; 56-87-1/Lysine; 5746-03-2/N(6)-(1-carboxyethyl)lysine; 5746-04-3/N(6)-carboxymethyllysine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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