Document Detail

Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study.
MedLine Citation:
PMID:  15851628     Owner:  NLM     Status:  MEDLINE    
We investigated the associations of pulse pressure (a measure of arterial stiffness) with the early glycation products hemoglobin A1c (HbA1c) and Amadori albumin and the advanced glycation end products pentosidine, Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine in a large group of type 1 diabetic individuals of the EURODIAB Prospective Complications Study. We did a cross-sectional nested case-control study from the EURODIAB Prospective Complications Study of 543 (278 men) European individuals with type 1 diabetes diagnosed at <36 years of age. We used linear regression analyses to investigate the association of pulse pressure with glycation products. Pulse pressure was significantly associated with plasma levels of Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine but not with HbA1c, Amadori albumin, and urinary levels of pentosidine. Regression coefficients adjusted for age, sex, mean arterial pressure, and duration of diabetes were 0.09 mm Hg (P=0.003) per 1 microM/M lysine Nepsilon-(carboxymethyl)lysine; 0.24 mm Hg (P=0.001) and -0.03 mm Hg (P=0.62) per 1 microM/M lysine Nepsilon-(carboxyethyl)lysine (in individuals with and without complications, respectively; P interaction=0.002); and 0.50 mm Hg (P=0.16) per 1% HbA1c; 0.07 mm Hg (P=0.12) per 1 U/mL Amadori albumin; and 0.77 mm Hg (P=0.48) per 1 nmol/mmol creatinine pentosidine. In young type 1 diabetic individuals, arterial stiffness is strongly associated with the advanced glycation end products Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine. These findings suggest that the formation of advanced glycation end products is an important pathway in the development of arterial stiffness in young type 1 diabetic individuals.
Miranda T Schram; Casper G Schalkwijk; Aart H Bootsma; John H Fuller; Nish Chaturvedi; Coen D A Stehouwer;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-25
Journal Detail:
Title:  Hypertension     Volume:  46     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2005-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-7     Citation Subset:  IM    
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Blood Pressure*
Case-Control Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 1 / blood,  physiopathology*
Follow-Up Studies
Hemoglobin A, Glycosylated / metabolism
Linear Models
Lysine / analogs & derivatives,  blood
Middle Aged
Multicenter Studies as Topic
Platelet Activating Factor / metabolism*
Prospective Studies
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/Platelet Activating Factor; 56-87-1/Lysine; 5746-03-2/N(6)-(1-carboxyethyl)lysine; 5746-04-3/N(6)-carboxymethyllysine

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