Document Detail

Advanced cardiac morphogenesis does not require heart tube fusion.
MedLine Citation:
PMID:  15361625     Owner:  NLM     Status:  MEDLINE    
The bilateral cardiac mesoderm migrates from the lateral region of the embryo to the ventral midline, where it fuses to form the primitive heart tube. It is generally accepted that migration and fusion are essential for subsequent stages of cardiac morphogenesis. We present evidence that, in Foxp4 mutant embryonic mice, each bilateral heart-forming region is capable of developing into a highly differentiated four-chambered mammalian heart in the absence of midline fusion. These data demonstrate that left-right chamber specification, cardiac looping, septation, cardiac myocyte differentiation, and endocardial cushion formation are preprogrammed in the precardiac mesoderm and do not require midline positional identity or heart tube fusion.
Shanru Li; Deying Zhou; Min Min Lu; Edward E Morrisey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  305     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-13     Completed Date:  2004-10-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1619-22     Citation Subset:  IM    
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Atrial Natriuretic Factor / metabolism
Basic Helix-Loop-Helix Transcription Factors
Body Patterning
Cell Differentiation
DNA-Binding Proteins / genetics,  metabolism
Endocardium / embryology
Endoderm / cytology,  metabolism
Forkhead Transcription Factors
Gene Targeting
Heart / embryology*
Heart Atria / embryology
Heart Ventricles / embryology
In Situ Hybridization
Mesoderm / physiology
Myocytes, Cardiac / cytology*
Proto-Oncogene Proteins c-myc / metabolism
Transcription Factors / metabolism
Zebrafish Proteins
Grant Support
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/DNA-Binding Proteins; 0/Forkhead Transcription Factors; 0/Foxp4 protein, mouse; 0/Hand1 protein, mouse; 0/Hand2 protein, mouse; 0/Proto-Oncogene Proteins c-myc; 0/Transcription Factors; 0/Zebrafish Proteins; 0/hand2 protein, zebrafish; 0/helix-loop-helix protein, eHAND; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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