| Advanced cardiac morphogenesis does not require heart tube fusion. | |
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MedLine Citation:
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PMID: 15361625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bilateral cardiac mesoderm migrates from the lateral region of the embryo to the ventral midline, where it fuses to form the primitive heart tube. It is generally accepted that migration and fusion are essential for subsequent stages of cardiac morphogenesis. We present evidence that, in Foxp4 mutant embryonic mice, each bilateral heart-forming region is capable of developing into a highly differentiated four-chambered mammalian heart in the absence of midline fusion. These data demonstrate that left-right chamber specification, cardiac looping, septation, cardiac myocyte differentiation, and endocardial cushion formation are preprogrammed in the precardiac mesoderm and do not require midline positional identity or heart tube fusion. |
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Authors:
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Shanru Li; Deying Zhou; Min Min Lu; Edward E Morrisey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 305 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-09-13 Completed Date: 2004-10-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1619-22 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Atrial Natriuretic Factor / metabolism Basic Helix-Loop-Helix Transcription Factors Body Patterning Cell Differentiation DNA-Binding Proteins / genetics, metabolism Endocardium / embryology Endoderm / cytology, metabolism Forkhead Transcription Factors Gene Targeting Heart / embryology* Heart Atria / embryology Heart Ventricles / embryology In Situ Hybridization Mesoderm / physiology Mice Morphogenesis Mutation Myocytes, Cardiac / cytology* Proto-Oncogene Proteins c-myc / metabolism Transcription Factors / metabolism Zebrafish Proteins |
| Grant Support | |
ID/Acronym/Agency:
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HL71589/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Basic Helix-Loop-Helix Transcription Factors; 0/DNA-Binding Proteins; 0/Forkhead Transcription Factors; 0/Foxp4 protein, mouse; 0/Hand1 protein, mouse; 0/Hand2 protein, mouse; 0/Proto-Oncogene Proteins c-myc; 0/Transcription Factors; 0/Zebrafish Proteins; 0/hand2 protein, zebrafish; 0/helix-loop-helix protein, eHAND; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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