| Advanced Glycation Endproducts and Diabetic Cardiovascular Disease. | |
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MedLine Citation:
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PMID: 22314141 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Advanced glycation endproducts (AGEs) are formed by a non-enzymatic reaction of sugar moieties (examples: glucose, fructose, glycolytic adducts) with the free amino groups on amino acid residues of proteins. A growing body of data demonstrate that AGEs are intimately involved in the pathophysiology of cardiovascular disease by stimulating inflammation, contributing to atheroma formation, and modulating vascular stiffness. The role of AGEs as potential biomarkers for disease presence and prognosis in diabetic patients remains an active area of study. Epidemiological and angiographic studies suggest that AGE levels may be related to the presence and extent of atherosclerosis, and may predict future outcomes in select populations. The present review summarizes the relevant evidence supporting the role of advanced glycation in promoting atherosclerosis as well as the epidemiologic studies demonstrating an association between AGEs and diabetic cardiovascular disease. |
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Authors:
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Anand Prasad; Peter Bekker; Sotirios Tsimikas |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-6 |
Journal Detail:
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Title: Cardiology in review Volume: - ISSN: 1538-4683 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9304686 Medline TA: Cardiol Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of California San Diego, CA Department of Medicine, Division of Cardiology, San Diego, CA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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