Document Detail


Advanced gestational age increases serum carbohydrate-deficient transferrin levels in abstinent pregnant women.
MedLine Citation:
PMID:  22878591     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Carbohydrate-deficient transferrin (%CDT) is a well-established and highly specific biomarker for sustained heavy consumption of alcohol. However, in pregnant women, the specificity of this biomarker might be affected by advanced gestational age, even after accounting for increased transferrin concentrations in pregnancy. The goal of this prospective study was to assess the variability in %CDT during pregnancy among alcohol-abstaining patients.
METHODS: Patients were recruited during one of the first prenatal care visits and followed-up to term. Abstinence was confirmed by maternal self-report and by alcohol biomarkers. Biomarkers assessed in the mother included serum gamma-glutamyltranspeptidase, urine ethyl glucuronide and ethyl sulfate, and whole blood phosphatidylethanol (PEth). In addition, PEth was measured in a dry blood spot card obtained from a newborn. For %CDT analysis, serum samples were collected at baseline and at term and analyzed by an internationally validated high-performance liquid chromatography and spectrophotometric detection method.
RESULTS: At recruitment (mean gestational age 22.6 ± 7.3 weeks), the mean %CDT concentration was 1.49 ± 0.30%, while at term, it increased to 1.67 ± 0.28% (P = 0.001). Using a conventional cutoff concentration %CDT >1.7%, 22.9 and 45.7% of the sample would be classified as 'positive' for this biomarker at recruitment and at term, respectively (P = 0.011 ).
CONCLUSION: These results suggest that a conventional cutoff of 1.7% might be too low for pregnant women and would generate false-positive results. We propose that %CDT >2.0% be used as a cutoff concentration indicative of alcohol exposure in pregnant women. The sensitivity of %CDT at this cutoff for heavy drinking during pregnancy needs to be assessed further.
Authors:
Ludmila N Bakhireva; Sandra Cano; William F Rayburn; Renate D Savich; Lawrence Leeman; Raymond F Anton; Daniel D Savage
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-08
Journal Detail:
Title:  Alcohol and alcoholism (Oxford, Oxfordshire)     Volume:  47     ISSN:  1464-3502     ISO Abbreviation:  Alcohol Alcohol.     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-10-17     Completed Date:  2013-07-29     Revised Date:  2014-04-13    
Medline Journal Info:
Nlm Unique ID:  8310684     Medline TA:  Alcohol Alcohol     Country:  England    
Other Details:
Languages:  eng     Pagination:  683-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age Factors
Alcohol Drinking / blood*,  epidemiology
Biological Markers / blood
Cohort Studies
Female
Follow-Up Studies
Gestational Age*
Humans
Pregnancy
Prospective Studies
Questionnaires
Temperance*
Transferrin / analogs & derivatives*,  metabolism
Young Adult
Grant Support
ID/Acronym/Agency:
K05 AA017435/AA/NIAAA NIH HHS; P20 AA017068/AA/NIAAA NIH HHS; P20 AA017608/AA/NIAAA NIH HHS; UL1 RR031977/RR/NCRR NIH HHS; UL1 TR000041/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Transferrin; 0/carbohydrate-deficient transferrin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cardiovascular responses and differential changes in mitogen-activated protein kinases following rep...
Next Document:  The high angiogenic activity in very early breast cancer enables reliable imaging with VEGFR2-target...