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Adults requiring cord blood transplants but have insufficient cell doses from a single cord blood unit can receive two units with successful engraftment kinetics similar to those of children receiving a single unit.
MedLine Citation:
PMID:  21338286     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We retrospectively evaluated neutrophil engraftment kinetics in 29 single versus nine double unit cord blood transplants (CBTs). All single CBTs were performed in pediatric patients (non-malignant/malignant diseases, 19/10), while all double CBTs were performed in adults (n = 8) and an adolescent (n = 1) with hematological malignancies. Median follow-up time was 2.3 years (range, 0.1-13.5 years). Engraftment was achieved in 69% and 89% of the single and double cord blood (CB) groups, respectively. Similarly, median day of engraftment was not different for the single versus the double CBTs, at 19 and 23 days, respectively, and the neutrophil engraftment kinetics was similar in the two groups. Our data indicate that adults without sufficient nucleated cell doses in a single CB unit may receive two units with similar engraftment kinetics to those of children receiving only a single unit.
Authors:
Gal Goldstein; Ronit Elhasid; Bella Bielorai; Avichai Shimoni; Ronit Yerushalmi; Imad Kassis; Arnon Nagler
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-21
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Pediatric Hemato-oncology and Bone Marrow Transplantation Department, The Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.
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