Document Detail


Adulteration of mustard cooking oil with argemone oil: do Indian food regulatory policies and antioxidant therapy both need revisitation?
MedLine Citation:
PMID:  17280492     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Consumption of adulterated mustard oil (Brassica nigra) with argemone oil (Argemone mexicana) even for a short duration leads to a clinical condition referred as epidemic dropsy. In humans, argemone oil contained in adulterated mustard oil causes oxidative stress and death of red blood cells via met-hemoglobin formation by altering pyridine nucleotide(s) and glutathione redox potential. Argemone oil contamination poses a serious threat to human health and should be checked by appropriate regulatory measures. Antioxidant therapy provides symptomatic relief and should be seriously considered for therapeutic interventions against argemone oil toxicity.
Authors:
Challagundla Kishore Babu; Subhash Kumar Khanna; Mukul Das
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  9     ISSN:  1523-0864     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-02-06     Completed Date:  2007-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  515-25     Citation Subset:  IM    
Affiliation:
Food Toxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / therapeutic use*
Edema / chemically induced,  drug therapy*
Erythrocytes / drug effects,  metabolism
Glutathione / metabolism
Glutathione Disulfide / metabolism
Humans
India
Lipid Peroxidation / drug effects
Models, Biological
Mustard Plant
NAD / metabolism
Nutrition Policy
Oxidation-Reduction / drug effects
Plant Oils / administration & dosage*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Plant Oils; 0/argemone oil; 27025-41-8/Glutathione Disulfide; 53-84-9/NAD; 70-18-8/Glutathione; 8007-40-7/mustard oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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