| Adult survival after prenatal exposure to the Dutch famine 1944--45. | |
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MedLine Citation:
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PMID: 11489148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Early life events may affect adult survival. We studied the effect of prenatal exposure to the Dutch famine 1944--45 on survival among 2254 people born in Amsterdam. Mortality up to age 50 was highest among those born before the famine (15.2%) and among those exposed to famine in late gestation (14.6%). It was lower among those exposed in mid- (11.2%) or early gestation (11.5%), and was lowest among those conceived after the famine (7.2%). These differences were caused by effects on mortality in the first year after birth and were mainly related to nutrition and infections. There was no effect of exposure to famine on mortality after the age of 18. The hazard ratio was 1.4 [0.8, 2.3] for those born before the famine, 1.1 [0.5, 2.3] for those exposed in late gestation, 0.8 [0.3, 1.8] for those exposed in mid-gestation and 1.1 [0.5, 2.5] in those exposed in early gestation compared with those conceived after the famine. We could not demonstrate effects of prenatal exposure to famine on cause-specific mortality after the age of 18. Because prenatal exposure to famine is linked to cardiovascular risk factors and disease, increased cardiovascular mortality in the future may be expected. |
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Authors:
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T J Roseboom; J H van der Meulen; C Osmond; D J Barker; A C Ravelli; O P Bleker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Paediatric and perinatal epidemiology Volume: 15 ISSN: 0269-5022 ISO Abbreviation: Paediatr Perinat Epidemiol Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-08-07 Completed Date: 2001-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709766 Medline TA: Paediatr Perinat Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 220-5 Citation Subset: IM |
Affiliation:
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Department of Clinical Epidemiology, Academic Medical Centre, Amsterdam, The Netherlands. t.j.roseboom@amc.uva.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Cohort Studies Female Humans Male Middle Aged Netherlands / epidemiology Nutrition Disorders / mortality Pregnancy Prenatal Exposure Delayed Effects* Starvation / mortality* |
| Comments/Corrections | |
Comment In:
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Paediatr Perinat Epidemiol. 2001 Jul;15(3):207
[PMID:
11489145
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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