Document Detail

Adult seronegative arthritis with antinuclear antibodies: a distinct group of patients with a different immunogenetic pattern from seropositive rheumatoid arthritis and a good outcome.
MedLine Citation:
PMID:  8789876     Owner:  NLM     Status:  MEDLINE    
To determine whether patients with rheumatoid factor (RF)-negative, antinuclear antibody (ANA)-positive oligo/polyarthritis are clinically and immunogenetically distinct from RF-positive rheumatoid arthritis (RA) and whether this subset of patients is the adult counterpart of early-onset pauciarticular juvenile chronic arthritis (EOPA JCA), we retrospectively studied 20 adult patients with RF-negative, ANA-positive arthritis. After a median duration of 3.25 years, only half of our patients had active synovitis. Seventy-five per cent were completely or reasonably self-sufficient according to the HAQ index. In contrast to the results in a group of 30 RF-positive RA patients, the percentage of patients having at least one of the susceptibility alleles (HLA DR1 or HLA-DR4) was not significantly higher in patients with RF-negative, ANA-positive arthritis than in controls. Furthermore, none of our RF-negative, ANA-positive patients had two susceptibility alleles, whereas 16.5% of RF-positive RA patients had both DR1 and DR4 or DR4 homozygosity. In conclusion, our results show that patients with RF-negative, ANA-positive oligo/polyarthritis are immunogenetically distinct from RF-positive RA and tend to have a better articular prognosis. The absence of typical ocular features and of the characteristic HLA-DR markers suggests that these patients cannot be considered as the adult counterpart of EOPA JCA.
A Saudan-Kister; C Gabay; J M Tiercy; B Mermillod; P A Guerne; T L Vischer
Related Documents :
1613696 - Polyamine levels in synovial tissues and synovial fluids of patients with rheumatoid ar...
17163236 - Methotrexate and hepatic toxicity in rheumatoid arthritis and psoriatic arthritis.
19823836 - Diagnostic value of synovial fluid anti-cyclic citrullinated peptide antibody for rheum...
14672886 - Bone loss in unclassified polyarthritis and early rheumatoid arthritis is better detect...
11673106 - Clinical characteristics of autoimmune hepatitis with histological features of acute he...
7956396 - Decreased heart rate variability in patients with chronic obstructive pulmonary disease.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Revue du rhumatisme (English ed.)     Volume:  63     ISSN:  1169-8446     ISO Abbreviation:  Rev Rhum Engl Ed     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-09     Completed Date:  1996-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313916     Medline TA:  Rev Rhum Engl Ed     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  IM    
Division de Rhumatologie, Hôpital Cantonal Universitaire de Genève, Switzlerand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Antibodies, Antinuclear / analysis*
Antirheumatic Agents / therapeutic use
Arthritis / drug therapy,  genetics*,  immunology*
Arthritis, Rheumatoid / genetics*,  immunology*
Cohort Studies
HLA-DR Antigens / analysis,  genetics
Middle Aged
Retrospective Studies
Rheumatoid Factor / analysis*
Treatment Outcome
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Antirheumatic Agents; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ultrastructural features of a solitary vitreous cyst.
Next Document:  A study of long-term survival, functional outcome and quality of life in patients with polymyositis ...