Document Detail


Adult seronegative arthritis with antinuclear antibodies: a distinct group of patients with a different immunogenetic pattern from seropositive rheumatoid arthritis and a good outcome.
MedLine Citation:
PMID:  8789876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether patients with rheumatoid factor (RF)-negative, antinuclear antibody (ANA)-positive oligo/polyarthritis are clinically and immunogenetically distinct from RF-positive rheumatoid arthritis (RA) and whether this subset of patients is the adult counterpart of early-onset pauciarticular juvenile chronic arthritis (EOPA JCA), we retrospectively studied 20 adult patients with RF-negative, ANA-positive arthritis. After a median duration of 3.25 years, only half of our patients had active synovitis. Seventy-five per cent were completely or reasonably self-sufficient according to the HAQ index. In contrast to the results in a group of 30 RF-positive RA patients, the percentage of patients having at least one of the susceptibility alleles (HLA DR1 or HLA-DR4) was not significantly higher in patients with RF-negative, ANA-positive arthritis than in controls. Furthermore, none of our RF-negative, ANA-positive patients had two susceptibility alleles, whereas 16.5% of RF-positive RA patients had both DR1 and DR4 or DR4 homozygosity. In conclusion, our results show that patients with RF-negative, ANA-positive oligo/polyarthritis are immunogenetically distinct from RF-positive RA and tend to have a better articular prognosis. The absence of typical ocular features and of the characteristic HLA-DR markers suggests that these patients cannot be considered as the adult counterpart of EOPA JCA.
Authors:
A Saudan-Kister; C Gabay; J M Tiercy; B Mermillod; P A Guerne; T L Vischer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Revue du rhumatisme (English ed.)     Volume:  63     ISSN:  1169-8446     ISO Abbreviation:  Rev Rhum Engl Ed     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-09     Completed Date:  1996-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313916     Medline TA:  Rev Rhum Engl Ed     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  313-20     Citation Subset:  IM    
Affiliation:
Division de Rhumatologie, Hôpital Cantonal Universitaire de Genève, Switzlerand.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alleles
Antibodies, Antinuclear / analysis*
Antirheumatic Agents / therapeutic use
Arthritis / drug therapy,  genetics*,  immunology*
Arthritis, Rheumatoid / genetics*,  immunology*
Cohort Studies
Female
HLA-DR Antigens / analysis,  genetics
Humans
Immunogenetics
Male
Middle Aged
Retrospective Studies
Rheumatoid Factor / analysis*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Antirheumatic Agents; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen; 9009-79-4/Rheumatoid Factor

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