Document Detail

Adult respiratory distress syndrome.
MedLine Citation:
PMID:  2688415     Owner:  NLM     Status:  MEDLINE    
The Adult Respiratory Distress Syndrome (ARDS) is a fulminant form of respiratory failure affecting many seriously ill patients. The early manifestations of ARDS are caused by increased permeability of the alveolo-capillary barrier leading to pulmonary edema, stiff lungs, and a large right-to-left intrapulmonary shunt. Polymorphonuclear leukocytes (PMNS) are involved in the pathogenesis of most ARDS, and multiple PMN mechanisms can effect pulmonary injury; interactions between PMN adherence, proteolytic enzyme release, and oxygen radical production are emphasized. ARDS therapy remains largely supportive and has had little impact on mortality. The complications of infection and multiorgan failure play important roles in determining ARDS outcome.
A R Dal Nogare
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  298     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-24     Completed Date:  1990-01-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  413-30     Citation Subset:  AIM; IM    
UTSWMC-Pulmonary Diseases, Dallas, Texas 75235-9034.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Cell Adhesion
Complement System Proteins / physiology
Endothelium, Vascular / pathology
Lipopolysaccharides / pharmacology
Neutrophils / physiology
Oxygen / physiology
Respiratory Distress Syndrome, Adult / diagnosis*,  etiology,  pathology,  physiopathology,  therapy
Tumor Necrosis Factor-alpha / physiology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Lipopolysaccharides; 0/Tumor Necrosis Factor-alpha; 7782-44-7/Oxygen; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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