Document Detail

Adult respiratory distress syndrome in cases of severe trauma--the prophylactic value of methylprednisolone sodium succinate.
MedLine Citation:
PMID:  3885438     Owner:  NLM     Status:  MEDLINE    
The more important known pathogenetic mechanisms apparently responsible for the development of adult respiratory distress syndrome (ARDS) are briefly discussed. Reactions in the development of ARDS for which corticosteroids are possibly beneficial are pointed out. A prospective study involving 92 patients was designed to determine the prophylactic value of methylprednisolone sodium succinate (MPSS) (Solu-Medrol; Upjohn) in preventing ARDS. MPSS was administered to 47 seriously injured patients and omitted from the management regimen of 45 patients comparable as regards age and severity of injury. The percentage of patients who developed ARDS was significantly lower in the group that received MPSS than in the control group.
C J van der Merwe; A F Louw; D Welthagen; H S Schoeman
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  67     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-05-07     Completed Date:  1985-05-07     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
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MeSH Terms
Methylprednisolone / analogs & derivatives*
Methylprednisolone Hemisuccinate / therapeutic use*
Middle Aged
Prospective Studies
Respiratory Distress Syndrome, Adult / etiology,  prevention & control*
Steroids / therapeutic use
Wounds and Injuries / complications*
Reg. No./Substance:
0/Steroids; 5GMR90S4KN/Methylprednisolone Hemisuccinate; X4W7ZR7023/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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