Document Detail


[Adult refractory Still disease with atypical articular manifestations: Efficacity of interleukin-6 antagonists (tocilizumab)].
MedLine Citation:
PMID:  22655584     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
INTRODUCTION: Tocilizumab is a humanized monoclonal antibody directed against interleukin-6 receptor and is beginning to be reported as effective in some cases of Still's disease refractory in adults (ASD). ASD is rare, heterogeneous, with unpredictable evolution. The distal destructive arthritis represents a possible complication.
PATIENT: We report an unusual case of adult-onset Still's disease with severe distal interphalangeal destructive arthritis with refractory early and prolonged remission after the first tocilizumab infusion.
CONCLUSION: Tocilizumab can be used in patients with refractory ASD after failure or intolerance of conventional treatments.
Authors:
A Rkiouak; K Ennibi; A Zinebi; Y Akhouad; A Reggad; M Rabhi; J Chaari
Publication Detail:
Type:  English Abstract; Journal Article     Date:  2012-04-10
Journal Detail:
Title:  Annales pharmaceutiques françaises     Volume:  70     ISSN:  0003-4509     ISO Abbreviation:  Ann Pharm Fr     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985176R     Medline TA:  Ann Pharm Fr     Country:  France    
Other Details:
Languages:  fre     Pagination:  163-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Affiliation:
Service de médecine interne A, hôpital militaire d'instruction Mohammed V, BP 10100, Rabat, Maroc.
Vernacular Title:
Atteintes articulaires atypiques au cours d'une maladie de Still de l'adulte réfractaire : efficacité des antagonistes de l'interleukine-6 (tocilizumab).
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