Document Detail

Adult rabbit offspring of mothers with secondary hypertension have increased blood pressure.
MedLine Citation:
PMID:  12623971     Owner:  NLM     Status:  MEDLINE    
Preexisting chronic hypertension complicates up to 5% of pregnancies and is associated with an increased risk of low-birth-weight babies. Studies suggest that an adverse intrauterine environment leading to low birth weight is linked to an increased risk of cardiovascular disease, including hypertension, in the adult. In this study, the blood pressure of offspring from mothers with hypertension were followed up into adulthood. Two-kidney, 1-wrapped hypertension was induced in 7 female rabbits; 5 other rabbits underwent sham surgery. Four weeks later, rabbits were mated, at which time mean arterial pressure was 118+/-3 and 87+/-5 mm Hg in the hypertensive and sham groups, respectively (P<0.001). The blood pressure of 30-week-old females was 89+/-2 mm Hg in the offspring of hypertensive (n=14) and 79+/-1 mm Hg in the offspring of normotensive (n=13) mothers (P<0.005). Also, plasma renin activity was significantly lower in the female offspring of hypertensive mothers at 10 weeks of age (P<0.05), suggesting that development of the renin-angiotensin system was altered. In contrast, male offspring from hypertensive and normotensive mothers had similar mean arterial pressure and plasma renin activity. In conclusion, maternal secondary hypertension can "program" hypertension in female adult offspring. The results also suggest that there are gender-specific differences in sensitivity to altered in utero environmental influences.
Kate M Denton; Rebecca L Flower; Kathleen M Stevenson; Warwick P Anderson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-02-03
Journal Detail:
Title:  Hypertension     Volume:  41     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-07     Completed Date:  2003-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  634-9     Citation Subset:  IM    
Department of Physiology, PO Box 13F, Monash University, Victoria, Australia 3800.
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MeSH Terms
Blood Pressure*
Body Weight
Hypertension / blood,  etiology*,  physiopathology
Pregnancy Complications, Cardiovascular / blood,  physiopathology*
Renin / blood
Sex Factors
Sodium Chloride / administration & dosage
Reg. No./Substance:
7647-14-5/Sodium Chloride; EC

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