| Adult-onset Still's disease in an oriental population: manifestations, course and outcome in 16 patients. | |
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MedLine Citation:
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PMID: 9588268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This retrospective descriptive study aims to characterise and compare the clinical manifestations, course and outcome of 16 Oriental patients with adult-onset Still's disease diagnosed in the last 4 years with published data based on Western populations and another Oriental (Japanese) series. Like the Japanese, we found a female preponderance, an older age at onset, and fewer patients with abdominal pain, myalgia, sore throat and serositis compared to the Western series. A longer delay in diagnosis occurred in patients lacking either arthritis or rash at presentation. Most patients had mild hyponatraemia and 2 patients had overt syndrome of inappropriate anti-diuretic hormone secretion. All patients showed a dissociation of elevated aldolase with normal to low creatine kinase levels. Over 50% relapsed within a year from diagnosis and needed slow-acting anti-rheumatic drugs as steroid-sparing agents. Two were given intravenous pulse cyclophosphamide therapy for progressive pneumonitis. Outcome was generally good with minimal functional impairment and no mortality. |
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Authors:
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E Lim; H H Chng |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Annals of the Academy of Medicine, Singapore Volume: 27 ISSN: 0304-4602 ISO Abbreviation: Ann. Acad. Med. Singap. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-07-16 Completed Date: 1998-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503289 Medline TA: Ann Acad Med Singapore Country: SINGAPORE |
Other Details:
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Languages: eng Pagination: 11-5 Citation Subset: IM |
Affiliation:
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Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Distribution Age of Onset Aged Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Female Humans Japan / ethnology Male Middle Aged Prevalence Prognosis Retrospective Studies Sex Distribution Singapore / epidemiology Steroids / therapeutic use Still's Disease, Adult-Onset / diagnosis*, drug therapy, ethnology* Survival Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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