| Adult-onset Still's disease in a patient over 80 years old successfully treated with low-dose methotrexate therapy. | |
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MedLine Citation:
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PMID: 17158115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on an 83-year-old Japanese woman with adult-onset Still's disease (AOSD), with marked hypercytokinemia (serum levels of ferritin (Fer) and interleukin (IL)-18 were markedly high). On seeing older patients with fever of unknown origin (FUO), particularly Asians, AOSD should be considered. Reduced doses of oral prednisolone following intravenous methylprednisolone (mPSL) therapy caused a flare-up of AOSD and led to Pneumocystis carinii (jeroveci) pneumonia. Low-dose methotrexate (MTX) therapy was administered as a steroid-sparing agent with good response. Our case suggests that in very elderly people, as in younger patients, MTX is useful for controlling AOSD with marked hypercytokinemia, and avoiding corticosteroid-induced adverse effects. |
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Authors:
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Miwa Kurasawa; Kazuhiko Kotani; Gotaro Kurasawa; Kousuke Shida; Shigeki Yamada; Toshihiko Tago |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-12-06 |
Journal Detail:
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Title: Age and ageing Volume: 36 ISSN: 0002-0729 ISO Abbreviation: Age Ageing Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-31 Completed Date: 2007-03-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375655 Medline TA: Age Ageing Country: England |
Other Details:
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Languages: eng Pagination: 104-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Nishiagatsuma Welfare Hospital, Naganohara, Japan. miwa-kr@zero.ad.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Anti-Inflammatory Agents / adverse effects, therapeutic use Antirheumatic Agents / therapeutic use* Cytokines / blood Dose-Response Relationship, Drug Drug Therapy, Combination Female Humans Methotrexate / therapeutic use* Methylprednisolone / adverse effects, therapeutic use Still's Disease, Adult-Onset / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antirheumatic Agents; 0/Cytokines; 59-05-2/Methotrexate; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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