Document Detail

Adult nesidioblastosis. An unusual cause of fasting hypoglycemia.
MedLine Citation:
PMID:  2729774     Owner:  NLM     Status:  MEDLINE    
Laidlaw coined the term nesidioblastosis in 1938 to characterize the neodifferentiation of the islet cells of Langerhans from pancreatic duct epithelium. It is well recognized in the pediatric population as a frequent cause of persistent neonatal hypoglycemia. However, its occurrence in adults is presumed to be rare and, therefore, it is not appreciated as a cause of hyperinsulinism. Three women, aged 29, 42, and 63, with adult onset hyperinsulinism secondary to nesidioblastosis are reported. All three patients required near-total pancreatectomy. The preoperative findings were consistent with hyperinsulinemic hypoglycemia as with insulinomas. Results of pancreatic imaging studies were normal in two patients and one patient had a pancreatic examination by computerized tomography and magnetic resonance imaging, with false-positive results. Two of the three patients had previously undergone a 50 per cent distal pancreatectomy in which the resected specimens were interpreted as normal in one patient and consistent with nesidioblastosis in the second. Both patients subsequently developed recurrent symptomatic hyperinsulinemic hypoglycemia that persisted despite dosage adjustments in diazoxide therapy. The oldest patient underwent a 95 per cent pancreatectomy at the initial surgical exploration because an insulinoma could not be identified. The other patients underwent a completion 95 per cent pancreatectomy. In both, histochemical examination of each specimen disclosed nesidioblastosis, characterized by clusters of islet cells interspersed throughout the exocrine tissue.
C McHenry; K Newell; G Chejfec; A Barbato; A M Lawrence; M Brooks; M A Emanuele; E Paloyan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  55     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-06-30     Completed Date:  1989-06-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  366-9     Citation Subset:  IM    
Department of Surgery, Loyola University Medical Center, Maywood, Illinois.
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MeSH Terms
Age Factors
Hypoglycemia / etiology*,  pathology
Middle Aged
Pancreatic Diseases / complications*,  pathology

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