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Adult height in Turner Syndrome girls after long-term growth hormone treatment.
MedLine Citation:
PMID:  19770097     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
We studied the adult height (AH) outcome, and factors likely to influence it, in Turner Syndrome (TS) girls treated with growth hormone (GH). A total of 25 TS girls treated with GH were compared with 10 TS girls not treated with GH. The percentage of girls who achieved normal third percentile was determined. Projected AH (PAH) was calculated according to height standard deviation score (HSDS) at the beginning of the treatment. Gain in height was determined as: AH - pretreatment PAH. The percentage of girls who achieved target range (midparental height +/- 2 SD) was determined. Multiple linear regression models were fitted on baseline variables- chronological age (CA), midparental height (MPH) and HSDS; and treatment variables- duration of oestrogen-free GH therapy and duration of GH therapy+oestrogens. As for baseline data: Median CA was 13.0 years (5.6-15.8). Mean HSDS was 0.25 +/- 1.1 SDS. PAH was 139.2 +/- 5.6 cm. MPH was 160.0 +/- 5.0 cm. As for follow up data: Median CA at onset oestrogens was 15.1 years (13.2-16.6). Median duration of GH therapy was 3.8 years (2.1-10.3). Median oestrogen-free GH period was 2.0 years (0.7-7.8), and median GH+oestrogens period, 1.8 years (1.0-3.2). Adult height: Mean AH was 150.4 +/- 7.0 cm in treated patients and 140.8 +/- 7.2 cm in the group not treated with GH (p=0.001). Fourteen (56%) girls achieved normal third percentile compared with an initially predicted 1 (4%). Gain in height was 11.2 +/- 3.7 cm. Thirteen (59%) girls reached an AH within target range. HSDS at the beginning of the treatment was the variable most strongly related to AH and duration of oestrogen-free GH period was the variable most strongly related to gain in height.
Authors:
Analia Morin; Luis M Guimarey; Maria Apezteguia; Zulma C Santucci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicina     Volume:  69     ISSN:  0025-7680     ISO Abbreviation:  Medicina (B Aires)     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0204271     Medline TA:  Medicina (B Aires)     Country:  Argentina    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Affiliation:
Sala de Endocrinología, Hospital de Niños Sor María Ludovica, La Plata. morinanalia@yahoo.com.ar
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