Document Detail

Adult cytomegalovirus inclusion retino-uveitis.
MedLine Citation:
PMID:  171958     Owner:  NLM     Status:  MEDLINE    
A 27-year-old male renal transplant recipient acquired cytomegalovirus (CMV) infection of both eyes. This was characterized early by a distinctive necrotic retinitis with discrete advancing edges. A large exudative retinal detachment and hypopyon developed in one eye, and cultures from the anterior chamber aspirate grew CMV. Cytomegalovirus was also isolated from the urine and throat; after serial negative base-line titers, CMV antibody titer became positive. At autopsy CMV was isolated from lung, esophagus, and kidney tissue. Light and electron microscopic studies demonstrated extensive necrosis and disruption of the sensory retina and retinal pigment epithelium with exudative retinal detachments. The diseased retinal cells contained a multiplicity of viral particles in various stages of maturity. Cytomegalic inclusion-bearing cells were demonstrated in the choroid of the more severely affected eye.
L C Chumbley; D M Robertson; T F Smith; R J Campbell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  80     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-01-26     Completed Date:  1976-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  807-16     Citation Subset:  AIM; IM    
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MeSH Terms
Cytomegalovirus / isolation & purification
Cytomegalovirus Infections / microbiology,  pathology*
Eye / pathology
Immunosuppression / adverse effects
Kidney Transplantation
Retinitis / microbiology,  pathology*
Transplantation, Homologous
Uveitis / microbiology,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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