Document Detail


Adult cystic fibrosis patients with and without infective exacerbations and their factor XII levels.
MedLine Citation:
PMID:  19525847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated haemostatic and inflammatory parameters in patients with cystic fibrosis in an attempt to understand a previous finding of low factor XII levels in this patient population. We selected two groups of patients, adults attending outpatient annual review clinic who were well, chronically inflammed and adult patients with an infective exacerbation requiring antibiotics or admission to hospital, acutely inflammed. We measured known positive acute phase haemostatic factors, fibrinogen and factor VIII. Antithrombin and factor XII were also measured as both these factors have been proposed to be negative acute phase proteins in in-vitro cell models. Interleukin-6 was also measured as the proposed modulator of these factors during inflammation. Activated factor XII was measured to exclude XII activation as a cause of the low XII activity levels. Cystic fibrosis patients admitted to hospital with infective exacerbations, showed significantly more evidence of inflammation than the annual review patients. Fibrinogen and factor VIII were higher and factor XII was lower in these patients. This work suggests that factor XII behaves as a negative acute phase protein with no signs of elevated activated XII levels in either group. This supports similar findings from in-vitro cell culture. This study also shows low antithrombin levels in both patient populations, although there was no statistical difference between groups, which is probably related to their liver disorder.
Authors:
Simon J Davidson; Shanti Paramothayan; Margaret E Hodson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  20     ISSN:  1473-5733     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  400-2     Citation Subset:  IM    
Affiliation:
Department of Haematology, Royal Brompton Hospital, UK. S.Davidson@rbht.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / analysis
Adult
Antithrombin III / analysis
Blood Coagulation Factors / analysis
Cystic Fibrosis / blood*,  complications
Disease Susceptibility
Factor VIII / analysis
Factor XII / analysis*
Factor XII Deficiency / blood,  etiology*
Factor XIIa / analysis
Female
Fibrinogen / analysis
Hemostasis
Humans
Infection / complications*
Inflammation / blood,  complications
Interleukin-6 / blood
Liver / metabolism
Male
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Blood Coagulation Factors; 0/F8 protein, human; 0/IL6 protein, human; 0/Interleukin-6; 9000-94-6/Antithrombin III; 9001-27-8/Factor VIII; 9001-30-3/Factor XII; 9001-32-5/Fibrinogen; EC 3.4.21.38/Factor XIIa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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