Document Detail


Adult cockatiels (Nymphicus hollandicus) at maintenance are more sensitive to diets containing excess vitamin A than to vitamin A-deficient diets.
MedLine Citation:
PMID:  12771336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this experiment was to examine the physiological responses of adult cockatiels at maintenance to dietary vitamin A (VA) concentrations, and to identify concentrations associated with deficiency and toxicity. Adult cockatiels at maintenance (n = 22, 2-3 y of age) were fed a diet of 0, 600, 3000 or 30,000 microg VA/kg (0, 2000, 10,000 or 100,000 IU), and monitored for signs of VA deficiency or toxicity for up to 706 d. The analyzed diet concentrations were 0, 835, 2815 and 24,549 microg/kg, respectively. After 269 d, birds fed the 30,000 microg/kg VA diet had greater plasma retinal concentrations, markedly intensified vocalization patterns, pancreatitis and multifocal accumulation of lymphocytes in the lamina propria of the duodenum compared to birds fed the 600 microg/kg diet (P < 0.05). The 3000 microg/kg VA diet induced increased plasma retinol, splenic hemosiderosis and altered vocalization patterns (P < 0.05), although not as striking as those induced by the 30,000 microg/kg VA diet. The secondary antibody response was reduced after 225 d and vocalization patterns were altered in birds fed 0 microg/kg VA (P < 0.05), but after almost 2 y there were no changes in body condition, plasma retinol, organ pathology or classical signs of deficiency such as squamous metaplasia of nasal epithelia. Thus, adult cockatiels at maintenance were more susceptible to VA toxicity than to VA deficiency and concentrations > or = 3000 microg VA/kg diet can cause toxicity. It is possible that disturbances in VA nutrition contribute to the widespread incidence of behavioral problems reported in companion birds.
Authors:
Elizabeth A Koutsos; Lisa A Tell; Leslie W Woods; Kirk C Klasing
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2003-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1898-902     Citation Subset:  IM    
Affiliation:
Department of Animal Science, School of Veterinary Medicine. California Animal Health and Food Safety Lab, University of California-Davis, Davis, CA 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Domestic
Antibody Formation
Bird Diseases / etiology*,  pathology,  physiopathology
Body Weight / drug effects
Diet
Disease Susceptibility
Dose-Response Relationship, Drug
Erythrocytes / immunology
Hypervitaminosis A / etiology,  veterinary*
Liver / metabolism
Nasal Lavage Fluid / cytology
Psittaciformes*
Sheep / blood
Vitamin A / administration & dosage*,  blood,  metabolism
Vitamin A Deficiency / etiology,  veterinary*
Vocalization, Animal / drug effects
Chemical
Reg. No./Substance:
11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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