Document Detail


Adult bone marrow-derived cells: regenerative potential, plasticity, and tissue commitment.
MedLine Citation:
PMID:  16237509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reconstitution of infarcted myocardium with functional new cardiomyocytes and vessels, a goal that only a few years ago would have been regarded as extravagant, is now actively pursued in numerous laboratories and clinical centers. Several recent studies in animals as well as humans have shown that transplantation of adult bone marrow-derived cells (BMCs) can improve left ventricular function and halt adverse remodeling after myocardial infarction. Differentiation of adult BMCs into cells of cardiac and vascular lineages has been proposed as a mechanism underlying these benefits and, indeed, differentiation of adult BMCs into cells of non-hematopoietic lineages, including cells of brain, skeletal muscle, heart, liver, and other organs, has been documented repeatedly both in vitro and in vivo. These results are in contrast with conventional definitions and dogma, according to which adult tissue-specific stem cells exhibit only restricted differentiation potential. Thus, these recent studies have sparked intense debate over the ability of adult BMCs to differentiate into non-hematopoietic tissues, and the regeneration of myocardium by differentiation of adult BMCs remains highly controversial. Because of the enormous clinical implications of BMC-mediated cardiac repair, numerous laboratories are currently addressing the feasibility of cardiac regeneration with BMCs and deciphering the mechanism underlying the beneficial effects. The purpose of this review is to critically examine the available evidence regarding the ability of adult BMCs to regenerate non-hematopoietic tissues and their utility in therapeutic cardiac regeneration.
Authors:
Buddhadeb Dawn; Roberto Bolli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Basic research in cardiology     Volume:  100     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-31     Completed Date:  2006-03-07     Revised Date:  2013-09-05    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  494-503     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA. buddha@louisville.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow Cells / cytology*
Cardiomyopathies / pathology,  therapy*
Humans
Myocardium / cytology*
Regeneration*
Stem Cell Transplantation / trends*
Grant Support
ID/Acronym/Agency:
HL-55757/HL/NHLBI NIH HHS; HL-68088/HL/NHLBI NIH HHS; HL-709897/HL/NHLBI NIH HHS; HL-76794/HL/NHLBI NIH HHS; HL-78825/HL/NHLBI NIH HHS; P01 HL078825/HL/NHLBI NIH HHS; R01 HL-72410/HL/NHLBI NIH HHS; R01 HL055757/HL/NHLBI NIH HHS; R01 HL068088/HL/NHLBI NIH HHS; R01 HL070897/HL/NHLBI NIH HHS; R01 HL076794/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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