Document Detail

Adult-Onset Still Disease (AOSD).
MedLine Citation:
PMID:  20453189     Owner:  NLM     Status:  MEDLINE    
Adult-onset Still disease (AOSD) is an uncommon clinical entity that predominantly affects young adults. One of the most common presentations of the disease is fever of unknown origin. Early diagnosis can be difficult because fever of unknown origin is more commonly seen with other conditions such as malignancy or infection. Ambiguity in presentation and lack of serologic markers make diagnosis difficult. We describe here an 18-year-old African-American man who presented with fever, sore throat, and arthritis at initial admission, with serology positive for both Mycoplasma pneumonia and Epstein-Barr infection. The patient was discharged without improvement. He was then readmitted with persistence of initial symptoms and, at that stage, he fulfilled the proposed diagnostic criteria of AOSD. The purpose of this case report is to describe the triggering infections that can initially mislead diagnosis and to review the literature about AOSD from a primary care perspective.
Egambaram Senthilvel; Aphrodite Papadakis; Michael McNamara; Iyabode Adebambo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Board of Family Medicine : JABFM     Volume:  23     ISSN:  1557-2625     ISO Abbreviation:  J Am Board Fam Med     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-05-10     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256526     Medline TA:  J Am Board Fam Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  418-22     Citation Subset:  IM    
Department of Family Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Echocardiography, Transesophageal
Epstein-Barr Virus Infections / blood
Fever of Unknown Origin
Glucocorticoids / therapeutic use
Immunosuppressive Agents / therapeutic use
Methotrexate / therapeutic use
Naproxen / therapeutic use
Pleural Effusion
Pneumonia, Mycoplasma / blood
Prednisone / therapeutic use
Still's Disease, Adult-Onset / blood,  diagnosis*,  drug therapy,  ultrasonography
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Glucocorticoids; 0/Immunosuppressive Agents; 22204-53-1/Naproxen; 53-03-2/Prednisone; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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