Document Detail


The adult mouse and human pancreas contain rare multipotent stem cells that express insulin.
MedLine Citation:
PMID:  21362568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The search for putative precursor cells within the pancreas has been the focus of extensive research. Previously, we identified rare pancreas-derived multipotent precursor (PMP) cells in the mouse with the intriguing capacity to generate progeny in the pancreatic and neural lineages. Here, we establish the embryonic pancreas as the developmental source of PMPs through lineage-labeling experiments. We also show that PMPs express insulin and can contribute to multiple pancreatic and neural cell types in vivo. In addition, we have isolated PMPs from adult human islet tissue that are also capable of extensive proliferation, self-renewal, and generation of multiple differentiated pancreatic and neural cell types. Finally, both mouse and human PMP-derived cells ameliorated diabetes in transplanted mice. These findings demonstrate that the adult mammalian pancreas contains a population of insulin(+) multipotent stem cells and suggest that these cells may provide a promising line of investigation toward potential therapeutic benefit.
Authors:
Simon R Smukler; Margot E Arntfield; Rozita Razavi; George Bikopoulos; Phillip Karpowicz; Raewyn Seaberg; Feihan Dai; Simon Lee; Rosemary Ahrens; Paul E Fraser; Michael B Wheeler; Derek van der Kooy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell stem cell     Volume:  8     ISSN:  1875-9777     ISO Abbreviation:  Cell Stem Cell     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-02     Completed Date:  2011-08-24     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  101311472     Medline TA:  Cell Stem Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  281-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Cell Aggregation
Cell Differentiation
Cell Proliferation
Diabetes Mellitus, Experimental / therapy
Gene Expression Profiling
Humans
Insulin / metabolism*
Islets of Langerhans / cytology,  metabolism
Mice
Multipotent Stem Cells / cytology*,  metabolism*,  transplantation
Neural Crest / cytology,  metabolism
Pancreas / cytology*
Phenotype
Grant Support
ID/Acronym/Agency:
089703//Wellcome Trust; MC_G1000734//Medical Research Council; //Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Insulin
Comments/Corrections
Comment In:
Cell Stem Cell. 2011 Mar 4;8(3):244-5   [PMID:  21362562 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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