Document Detail


Adult cancers near high-voltage overhead power lines.
MedLine Citation:
PMID:  23337237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Extremely low-frequency magnetic fields are designated as possibly carcinogenic in humans, based on an epidemiologic association with childhood leukemia. Evidence for associations with adult cancers is weaker and inconsistent.
METHODS: We conducted a case-control study to investigate risks of adult cancers in relation to distance and extremely low-frequency magnetic fields from high-voltage overhead power lines using National Cancer Registry Data in England and Wales, 1974-2008. The study included 7823 leukemia, 6781 brain/central nervous system cancers, 9153 malignant melanoma, 29,202 female breast cancer cases, and 79,507 controls frequency-matched on year and region (three controls per case except for female breast cancer, one control per case) 15-74 years of age living within 1000 m of a high-voltage overhead power line.
RESULTS: There were no clear patterns of excess risk with distance from power lines. After adjustment for confounders (age, sex [except breast cancer], deprivation, rurality), for distances closest to the power lines (0-49 m) compared with distances 600-1000 m, odds ratios (ORs) ranged from 0.82 (95% confidence interval = 0.61-1.11; 66 cases) for malignant melanoma to 1.22 (0.88-1.69) for brain/central nervous system cancer. We observed no meaningful excess risks and no trends of risk with magnetic field strength for the four cancers examined. In adjusted analyses at the highest estimated field strength, ≥1000 nanotesla (nT), compared with <100 nT, ORs ranged from 0.68 (0.39-1.17) for malignant melanoma to 1.08 (0.77-1.51) for female breast cancer.
CONCLUSION: Our results do not support an epidemiologic association of adult cancers with residential magnetic fields in proximity to high-voltage overhead power lines.
Authors:
Paul Elliott; Gavin Shaddick; Margaret Douglass; Kees de Hoogh; David J Briggs; Mireille B Toledano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  24     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-23     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  184-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Case-Control Studies
Electromagnetic Fields / adverse effects*
England / epidemiology
Environmental Exposure / adverse effects*,  statistics & numerical data
Female
Humans
Incidence
Logistic Models
Male
Middle Aged
Neoplasms / epidemiology*
Odds Ratio
Registries
Residence Characteristics / statistics & numerical data*
Wales / epidemiology
Grant Support
ID/Acronym/Agency:
G0801056//Medical Research Council; RRX106//Department of Health
Comments/Corrections
Comment In:
Epidemiology. 2013 Mar;24(2):191-2   [PMID:  23377088 ]
Epidemiology. 2013 Sep;24(5):782   [PMID:  23903888 ]
Epidemiology. 2013 Sep;24(5):782-3   [PMID:  23903889 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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