| Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women. | |
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MedLine Citation:
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PMID: 22848798 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Purpose. We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population. Methods. We included 1,457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer. Results. We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with <5 kg/m(2) change of BMI, women who reported moderate (5-10 kg/m(2)) and large (>10 kg/m(2)) BMI changes since their 20s had OR estimates of 1.54 (95% CI = 1.09-2.19) and 1.45 (95% CI = 0.90-2.33), respectively (P for trend = 0.05). Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95% CI = 1.02-3.05) and 2.21 (95% CI = 1.09-4.45), respectively (P for trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users. Similar associations were observed for BMI changes since the 30s decade. There was no association among HRT users. Conclusion. Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT. |
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Authors:
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Lyla Blake-Gumbs; Zhengyi Chen; Cheryl L Thompson; Nathan A Berger; Thomas C Tucker; Li Li |
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Publication Detail:
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Type: Journal Article Date: 2012-07-09 |
Journal Detail:
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Title: Journal of obesity Volume: 2012 ISSN: 2090-0716 ISO Abbreviation: J Obes Publication Date: 2012 |
Date Detail:
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Created Date: 2012-07-31 Completed Date: 2012-08-23 Revised Date: 2013-04-02 |
Medline Journal Info:
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Nlm Unique ID: 101526295 Medline TA: J Obes Country: United States |
Other Details:
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Languages: eng Pagination: 857510 Citation Subset: - |
Affiliation:
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Department of Family Medicine and Community Health, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-7136, USA. |
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