| Adsorption of small biological molecules on silica from diluted aqueous solutions: quantitative characterization and implications to the Bernal's hypothesis. | |
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MedLine Citation:
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PMID: 7659402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To describe quantitatively the adsorption of prebiotically important compounds of low molecular weight (amino acids, short linear peptides, cyclic dipeptides, the Krebs's cycle and other carboxylic acids, nucleosides and related phosphates) on silica surface from diluted neutral aqueous solutions, equilibrium constants (K) and free energies (-delta G) of adsorption were determined from the retention values measured by means of high-performance liquid chromatography on a silica gel column and from the isotherms measured under static conditions. For most carboxylic acids (including amino acids and linear peptides) -delta G values were negative and K < 1, thus showing very weak adsorption. Cyclic dipeptides (2,5-piperazinediones) exhibited higher adsorbability; -delta G > 0 and K > 1 were found for most of them. Influence of the structure of alpha-substituent on the adsorbability is analyzed. A linear dependence of -delta G on the number of aliphatic carbon atoms in a sorbate molecule was found for the series of aliphatic bifunctional amino acids, related dipeptides and 2,5-piperazinediones, as well as for the row from glycine to triglycyl glycine. The adsorption of nucleosides and their phosphates is characterized by much higher K and -delta G values (of the order of 10(2) and 10(4), respectively). The adsorption data available from our work and literature are summarized and discussed with implications to the Bernal's hypothesis on the roles of solid surfaces in the prebiotic formation of biopolymers from monomeric 'building blocks'. |
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Authors:
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V A Basiuk; Gromovoy TYu; E G Khil'chevskaya |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life Volume: 25 ISSN: 0169-6149 ISO Abbreviation: Orig Life Evol Biosph Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-10-02 Completed Date: 1995-10-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610391 Medline TA: Orig Life Evol Biosph Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 375-93 Citation Subset: IM; S |
Affiliation:
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Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Mexico, D.F. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Amino Acid Sequence Amino Acids / isolation & purification Biogenesis* Biopolymers / chemistry, isolation & purification* Carboxylic Acids / isolation & purification Kinetics Models, Biological Molecular Sequence Data Nucleosides / isolation & purification Oligopeptides / chemistry, isolation & purification Silicon Dioxide Solutions Thermodynamics Water |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Biopolymers; 0/Carboxylic Acids; 0/Nucleosides; 0/Oligopeptides; 0/Solutions; 7631-86-9/Silicon Dioxide; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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