| Adsorption of proteins on a lipid bilayer. | |
| | |
MedLine Citation:
|
PMID: 20386900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In our analysis of protein adsorption on a lipid bilayer, the protein surface is considered to contain one or a few charged spots, and the bilayer contains a significant amount of lipids with oppositely charged head groups. After adsorption, a folded protein is assumed to change its shape slightly due to the electrostatic attraction, so that one of the spots forms a flat contact with the oppositely charged lipid heads of the lipid bilayer. With realistic parameters, this model predicts that the contribution of electrostatic interactions to the protein adsorption energy per charged amino acid-lipid pair is 16-25 kJ/mol. Thus, a few (four or five) pairs is sufficient for irreversible adsorption. |
| | |
Authors:
|
Vladimir P Zhdanov; Bengt Kasemo |
Publication Detail:
|
Type: Journal Article Date: 2010-04-13 |
Journal Detail:
|
Title: European biophysics journal : EBJ Volume: 39 ISSN: 1432-1017 ISO Abbreviation: Eur. Biophys. J. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-22 Completed Date: 2011-01-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8409413 Medline TA: Eur Biophys J Country: Germany |
Other Details:
|
Languages: eng Pagination: 1477-82 Citation Subset: IM |
Affiliation:
|
Department of Applied Physics, Chalmers University of Technology, 412 96 Göteborg, Sweden. zhdanov@catalysis.ru |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adsorption Lipid Bilayers / chemistry*, metabolism Protein Folding Proteins / chemistry*, metabolism Static Electricity Thermodynamics |
| Chemical | |
Reg. No./Substance:
|
0/Lipid Bilayers; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dominance of epiphytic filamentous Thiothrix spp. on an aquatic macrophyte in a hydrothermal vent fl...
Next Document: Low-dose non-enhanced CT versus full-dose contrast-enhanced CT in integrated PET/CT studies for the ...