| Adsorption of bile acid by chitosan salts prepared with cinnamic acid and analogue compounds. | |
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MedLine Citation:
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PMID: 16909945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A chitosan (CS) powder treated with cinnamic acid and an analogue compound (CN) was prepared as CS-CN. Using it, bile acid adsorption by CS-CN and the release of CN were investigated in vitro. When CS-CN was soaked in a taurocholate solution, it released CN and simultaneously adsorbed the bile acid. For CS-CN prepared with cinnamic acid, the amount of CN released was 0.286 +/- 0.001 mmol/g CS-CN; the amount of taurocholate adsorbed was 0.284 +/- 0.003 mmol/g CS-CN. These two functions were recognized on alginate or pectin gel beads containing CS-CN. The amount of released CN was altered extensively by the species of CN used for gel-bead preparation. Results suggest that CS-CN is a candidate for complementary medicine to prevent lifestyle-related diseases. |
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Authors:
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Yoshifumi Murata; Kumiko Nagaki; Kyouko Kofuji; Fujiko Sanae; Hitoshi Kontani; Susumu Kawashima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomaterials science. Polymer edition Volume: 17 ISSN: 0920-5063 ISO Abbreviation: J Biomater Sci Polym Ed Publication Date: 2006 |
Date Detail:
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Created Date: 2006-08-16 Completed Date: 2006-10-31 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 9007393 Medline TA: J Biomater Sci Polym Ed Country: Netherlands |
Other Details:
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Languages: eng Pagination: 781-9 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa 920-1181, Japan. y-murata@hokuriku-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption* Alginates / chemistry Antioxidants / chemistry Bile Acids and Salts / chemistry* Chitosan / metabolism*, pharmacokinetics* Cinnamates / chemistry* Coumaric Acids / chemistry Gastric Juice / metabolism Glucuronic Acid / chemistry Glycocholic Acid / chemistry, pharmacokinetics Hexuronic Acids / chemistry Hydrogel / metabolism Models, Biological Pharmaceutical Preparations / chemical synthesis Powders / chemistry Taurocholic Acid / chemistry Taurodeoxycholic Acid / chemistry Vanillic Acid / chemistry X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
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0/Alginates; 0/Antioxidants; 0/Bile Acids and Salts; 0/Cinnamates; 0/Coumaric Acids; 0/Hexuronic Acids; 0/Pharmaceutical Preparations; 0/Powders; 121-34-6/Vanillic Acid; 25852-47-5/Hydrogel; 475-31-0/Glycocholic Acid; 516-50-7/Taurodeoxycholic Acid; 576-37-4/Glucuronic Acid; 621-82-9/cinnamic acid; 81-24-3/Taurocholic Acid; 9005-32-7/alginic acid; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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