| Adropin deficiency is associated with increased adiposity and insulin resistance. | |
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MedLine Citation:
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PMID: 22318315 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Adropin is a secreted peptide that improves hepatic steatosis and glucose homeostasis when administered to diet-induced obese mice. It is not clear if adropin is a peptide hormone regulated by signals of metabolic state. Moreover, the significance of a decline in adropin expression with obesity with respect to metabolic disease is also not clear. We investigated the regulation of serum adropin by metabolic status and diet. Serum adropin levels were high in chow-fed conditions and were suppressed by fasting and diet-induced obesity. High adropin levels were observed in mice fed a high-fat low carbohydrate diet, while lower levels were observed in mice fed a low fat high carbohydrate diet. To investigate the role of adropin deficiency in metabolic homeostasis, we generated adropin knockout mice (AdrKO) on the C57BL/6J background. AdrKO displayed a 50%-increase in increase in adiposity, although food intake and energy expenditure were normal. AdrKO also exhibited dyslipidemia and impaired suppression of endogenous glucose production in hyperinsulinemic-euglycemic clamp conditions, suggesting insulin resistance. While homo- and heterozygous carriers of the null adropin allele exhibited normal diet-induced obesity relative to controls, impaired glucose tolerance associated with weight gain was more severe in both groups. In summary, adropin is a peptide hormone regulated by fasting and feeding. In fed conditions, adropin levels are regulated dietary macronutrients, and increase with dietary fat content. Adropin is not required for regulating food intake, however it's functions impact on adiposity and are involved in preventing insulin resistance, dyslipidemia and impaired glucose tolerance. |
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Authors:
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K Ganesh Kumar; Jingying Zhang; Su Gao; Jari Rossi; Owen P McGuinness; Heather H Halem; Michael D Culler; Randall L Mynatt; Andrew A Butler |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-09 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: - ISSN: 1930-7381 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL 33458. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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