| Adrenomedullin suppresses atrial natriuretic factor (ANF) secretion from isolated atrium. | |
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MedLine Citation:
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PMID: 9749824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atrial natriuretic factor (ANF) secretion was studied using isolated perfused right atria prepared from rats. Adrenomedullin (ADM), a recently identified 52-amino acid peptide whose biological activity has a striking resemblance to that of ANF, was added to the perfusate at a concentration of 1 microg/ml. The concentration of ANF secreted into the perfusate was measured by radioimmunoassay, under basal conditions (atrial wall unstressed), and during atrial distention (intraluminal pressure raised to 4 and to 6 cm water). It was found that basal secretion of ANF was not altered by ADM. However, when intraluminal pressure was raised, there was a significantly smaller increase in ANF secretion in the ADM-infused atria than in the control atria. It is concluded that ADM significantly reduces stretch-induced secretion of ANF, while having only minimal effects on basal secretion. Such an inhibitory mechanism would ensure the necessary negative feedback mechanism to counter the previously-reported stimulatory actions of ANF on ADM secretion. Moreover, these results support the hypothesis that ADM could be responsible for the reduction in stretch-induced ANF release observed during pregnancy. |
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Authors:
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S Kaufman; Y Deng |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 63 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1998 |
Date Detail:
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Created Date: 1998-10-07 Completed Date: 1998-10-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1017-22 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Alberta, Edmonton, Canada. susan.jacobs@ualberta.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin Animals Atrial Natriuretic Factor / secretion* Blood Pressure / drug effects Cardiotonic Agents / pharmacology* Heart / drug effects* Heart Atria / drug effects, metabolism Male Myocardium / metabolism* Peptides / pharmacology* Radioimmunoassay Rats Rats, Sprague-Dawley Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Peptides; 0/Vasodilator Agents; 148498-78-6/Adrenomedullin; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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